01Product

L-Tyrosine

At a glance

L-Tyrosine from Zhicheng Bio — supply summary

Zhicheng Bio supplies bulk L-Tyrosine, CAS 60-18-4, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.

Supplier: Zhicheng Bio, Shanghai, China
CAS number: 60-18-4
Molecular formula: C9H11NO3
Availability: Made to order
Documents: Batch CoA with every shipment; spec sheet and MSDS on request
Packing: 25 kg cartons or bags, adjustable
PubChem CID: 6057
How to get a price: Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published

Amino Acids In stock

L-Tyrosine

CAS 60-18-4 · C9H11NO3

Bulk L-Tyrosine for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.

$4.87 – $5.46 /kg by order volume · indicative, ex-Shanghai

Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.

Category: Amino Acids

Availability: In stock

Packing: 25 kg bags, cartons or drums (standard)

Key supply points

Supplied against your target specification — USP / FCC / JP monograph where applicable
Recent batch COA provided with the quotation, before you commit
Consolidates with other SKUs into one shipment out of Shanghai
Third-party lab verification available pre-shipment on request

Documentation with every batch

COA per batchSpec SheetMSDS / SDSExport docs

Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.

Request COA & Quote Use the RFQ form

Shipping & Lead Time

Estimate freight for this product

In stock

Destination region Quantity (kg)

Air FreightFast

Transit: —
Est. freight *: —
Total door-to-port: —

Sea LCLValue

Transit: —
Est. freight *: —
Total door-to-port: —

Request Exact Quote

Documentation-first

COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.

Ready-stock depth

Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.

Certified supply chain

Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.

Flexible export

25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.

02Identity & properties

Identity & properties

Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.

CAS No.	60-18-4
Molecular Formula	C9H11NO3
Molecular Weight	181.19
EINECS	200-460-4
Synonyms	L-Tyrosine, L-Tyr, Y, (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid, 4-hydroxy-L-phenylalanine
Appearance	Colourless silky needles or white crystalline powder, odourless
Solubility	Water only 0.479 g/L at 25 °C (Merck reports 0.453 g/L at 25 °C) — the least water-soluble product in this range by two orders of magnitude. Insoluble in absolute alcohol, ether and acetone; soluble in alkaline solutions and in dilute mineral acid; slightly soluble in acetic acid.
Pharmacopoeial reference	FCC · JP

03Specifications

Specifications

Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.

Parameter	Specification	Test method
Isoelectric point	5.66	Literature value
Assay (as-is / dried basis)	—	Titration or HPLC per the applicable monograph
Appearance	—	Visual
Identification	—	IR / specific optical rotation per monograph
Specific optical rotation	—	Polarimetry
Loss on drying	—	Gravimetric
Residue on ignition / sulphated ash	—	Gravimetric
Chloride	—	Per monograph
Sulphate	—	Per monograph
Iron	—	Per monograph
Other amino acids / related substances	—	TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)	—	ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)	—	USP <61>/<62> or equivalent

A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.

04Formulation & handling notes

Formulation & handling notes

The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.

Tyrosine's defining formulation constraint is that it is essentially insoluble in water — 0.479 g/L at 25 °C, which is about 200 times less soluble than glutamine and 2,000 times less soluble than lysine. A 500 mg dose needs more than a litre of water at neutral pH. This single number rules tyrosine out of clear ready-to-drink beverages at any meaningful dose, and it is the reason tyrosine appears in capsules and powders rather than in shots.

The way around it is pH, not co-solvent. Tyrosine is soluble in alkaline solutions and in dilute mineral acid but insoluble in absolute alcohol, ether and acetone. Moving well away from the isoelectric point of 5.66 is the only lever that works — which is exactly why N-acetyl-L-tyrosine and tyrosine salts exist as premium alternatives.

In a suspension or a 'shake and drink' powder, tyrosine is the ingredient that will settle out and cake in the bottom of the bottle. If your product is a powder-in-water format, tell your customers to drink it promptly, or reformulate.

It has three ionisable groups — pK values of 2.20 (carboxyl), 9.11 (amine) and 10.07 (phenol) — the phenol being unique to tyrosine among the products here. That phenolic hydroxyl is also an oxidation and discolouration site, so a tyrosine-containing wet system can pink or brown over shelf life.

It is the most thermally stable item in the range, decomposing at about 343 °C, so bar extrusion and hot processing are not a constraint — solubility is.

Tyrosine and phenylalanine differ by one hydroxyl and both absorb in the UV. If your assay is a UV method on a multi-ingredient blend, they will interfere with each other; ask for a chromatographic assay.

Because the free amino acid is so insoluble, crystal habit matters more than usual: it crystallises as fine silky needles, which flow and pack very differently from a granular powder. Get bulk and tapped density before you fix a capsule or scoop size.

05Applications

Applications

B2B manufacturing use only — no finished-product or health claims.

Focus, stress-resilience and cognitive-support formulations

Pre-workout powders and capsules

Free-form amino acid and EAA blends

Clinical and enteral nutrition

Tablets and capsules (dry formats, for the reason below)

06Regulatory status by market

Regulatory status by market

Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.

Market	Status	Basis
United States	Listed by name in FDA's food-additive regulation for amino acids as 'L-Tyrosine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 4.3 percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111.	21 CFR 172.320(a), (b), (c)(4), (e)
European Union	Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice.	Directive 2002/46/EC (food supplements); national member-state rules
Japan	An Official Monograph titled 'L-Tyrosine' is listed in the Japanese Pharmacopoeia, Eighteenth Edition. Monograph existence only — no limits transcribed.	JP XVIII, Official Monographs
China	Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.	GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements

07Selected research

Selected research

Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.

These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.

A review of tyrosine supplementation in clinical and healthy populations concluded that reported effectiveness varies considerably, that the potential for treating clinical disorders appears limited, and that the potential for enhancing physical exercise appears minimal. Jongkees BJ, Hommel B, Kühn S, Colzato LS. J Psychiatr Res. 2015;70:50-57. PMID 26424423 DOI 10.1016/j.jpsychires.2015.08.014 Source
In 21 cadets during a military combat training course, a protein-rich drink containing 2 g tyrosine daily for five days was associated with better performance on a memory and a tracking task and lower systolic blood pressure than an isocaloric carbohydrate-rich drink; no effects on mood were found. Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Brain Res Bull. 1999;48(2):203-209. PMID 10230711 DOI 10.1016/s0361-9230(98)00163-4 Source
In a double-blind within-subjects study of 19 volunteers undergoing cold-water immersion, cold exposure impaired match-to-sample memory and choice reaction time, and tyrosine consumption (total 300 mg/kg) was examined as a countermeasure to those decrements. Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Physiol Behav. 2007;92(4):575-582. PMID 17585971 DOI 10.1016/j.physbeh.2007.05.003 Source

08Packing, storage & lead time

Packing, storage & lead time

Standard packing	25 kg bags, cartons or drums
Private packing	Custom packing & labeling available for regular customers
Storage	Cool, dry place, sealed in original packaging
Lead time	In stock
Shipping	Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane

09Procurement FAQ

Procurement FAQ

01Can I put L-tyrosine in a ready-to-drink beverage?

Realistically, no — not at a functional dose. Free L-tyrosine dissolves at only 0.479 g/L in water at 25 °C, so a 500 mg serving needs more than a litre. Tyrosine belongs in capsules, tablets and dry powders. If you need a liquid format, look at more soluble derivatives and salts.

02Will raising or lowering the pH help?

It is the only thing that will. Tyrosine is soluble in alkaline solutions and in dilute mineral acid and insoluble in alcohol, ether and acetone — so moving well away from its isoelectric point of 5.66 is the lever. Co-solvents do not work.

03My tyrosine powder blend settles out in water. Is the material at fault?

No — that is tyrosine behaving normally. It is by far the least soluble item in our range. For a shake-and-drink format, either accept a suspension and label it as such, or reformulate.

04Why does my tyrosine-containing liquid discolour?

The phenolic hydroxyl group, which is unique to tyrosine among the amino acids we supply, is an oxidation site. Pink or brown drift over shelf life in a wet system is the usual symptom. Consider oxygen headspace, chelation of trace metals and antioxidant strategy.

05How much do you hold?

About 2.8 tonnes in ready stock out of Shanghai. Ask us for bulk and tapped density with the specification sheet — tyrosine crystallises as fine needles and packs differently from most amino acids, which matters for capsule and scoop filling.

06What is the MOQ for L-Tyrosine?

MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.

07Can I get a sample of L-Tyrosine before ordering?

Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.

10Related