01Product

L-Glutamine FCC

At a glance

L-Glutamine from Zhicheng Bio — supply summary

Zhicheng Bio supplies bulk L-Glutamine (FCC), CAS 56-85-9, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Sourced to order — about 1 week to Shanghai port. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.

Supplier: Zhicheng Bio, Shanghai, China
CAS number: 56-85-9
Molecular formula: C5H10N2O3
Grade / specification: FCC
Availability: Made to order
Documents: Batch CoA with every shipment; spec sheet and MSDS on request
Packing: 25 kg cartons or bags, adjustable
PubChem CID: 5961
How to get a price: Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published

Amino Acids ~1 week

L-Glutamine

FCC

CAS 56-85-9 · C5H10N2O3

Bulk L-Glutamine for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.

$7.90 – $8.85 /kg by order volume · indicative, ex-Shanghai

Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.

Category: Amino Acids

Availability: Sourced to order — about 1 week to Shanghai port

Packing: 25 kg bags, cartons or drums (standard)

Key supply points

Supplied against your target specification — USP / FCC / JP monograph where applicable
Recent batch COA provided with the quotation, before you commit
Consolidates with other SKUs into one shipment out of Shanghai
Third-party lab verification available pre-shipment on request

Documentation with every batch

COA per batchSpec SheetMSDS / SDSExport docs

Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.

Request COA & Quote Use the RFQ form

Shipping & Lead Time

Estimate freight for this product

~1 weekSourced to order — about 1 week to Shanghai port

Destination region Quantity (kg)

Air FreightFast

Transit: —
Est. freight *: —
Total door-to-port: —

Sea LCLValue

Transit: —
Est. freight *: —
Total door-to-port: —

Request Exact Quote

Documentation-first

COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.

Ready-stock depth

Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.

Certified supply chain

Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.

Flexible export

25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.

02Identity & properties

Identity & properties

Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.

CAS No.	56-85-9
Molecular Formula	C5H10N2O3
Molecular Weight	146.14
EINECS	200-292-1 (PubChem also lists 230-006-0 and 105-459-1)
Synonyms	L-Glutamine, L-Gln, Q, (2S)-2,5-diamino-5-oxopentanoic acid, levoglutamide
Appearance	White crystals or crystalline powder, odourless
Solubility	Water 41.3 g/L at 25 °C. Strongly temperature-dependent: one gram dissolves in 56.7 mL of water at 0 °C, 38.5 mL at 18 °C and 20.8 mL at 30 °C. Practically insoluble in methanol (3.5 mg/100 mL at 25 °C), ethanol (0.46 mg/100 mL at 23 °C), ether, benzene, acetone, ethyl acetate and chloroform.
Pharmacopoeial reference	FCC (claimed grade — see note)

03Specifications

Specifications

Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.

Parameter	Specification	Test method
pH (aqueous solution)	5-6 at 14.6 g/L, 25 °C	Potentiometric
Ammonium	—	Per monograph
Assay (as-is / dried basis)	—	Titration or HPLC per the applicable monograph
Appearance	—	Visual
Identification	—	IR / specific optical rotation per monograph
Specific optical rotation	—	Polarimetry
Loss on drying	—	Gravimetric
Residue on ignition / sulphated ash	—	Gravimetric
Chloride	—	Per monograph
Sulphate	—	Per monograph
Iron	—	Per monograph
Other amino acids / related substances	—	TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)	—	ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)	—	USP <61>/<62> or equivalent

A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.

04Formulation & handling notes

Formulation & handling notes

The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.

Glutamine's solubility is the most temperature-sensitive of any amino acid on this list, and the numbers are worth memorising: 1 g needs 56.7 mL of water at 0 °C, 38.5 mL at 18 °C but only 20.8 mL at 30 °C. A concentrate that dissolves cleanly in a warm mixing tank can throw crystals when the pallet sits in a cold warehouse. Design your dissolution target at the coldest temperature the product will see, not at ambient.

It is practically insoluble in the usual organic solvents — 3.5 mg/100 mL in methanol, 0.46 mg/100 mL in ethanol — which rules out alcohol-based tincture and non-aqueous liquid formats entirely.

It melts with decomposition at about 185 °C, the lowest decomposition temperature of any amino acid on this list (compare leucine at 293 °C, tyrosine at 343 °C). Anything involving a hot die, a bar extruder or a spray-dry inlet needs to be checked against that ceiling rather than against a generic amino-acid assumption.

The amide side chain is the reactive part. An ammonium limit on the specification is more informative about how a batch has been stored and shipped than the assay is, because ammonia is what the amide releases when the material has been held wet or warm. Ask for it explicitly.

A 1.46% solution sits at pH 5-6, close enough to neutral that glutamine will not fight an existing beverage buffer — a real advantage over arginine base (alkaline) or citrulline malate (acidic) in a multi-ingredient pre-workout.

This is Zhicheng Bio's deepest single position at over 23 tonnes, which matters practically: glutamine is usually the highest-inclusion amino acid in a recovery formula, so it is the one where container-scale availability decides whether a launch is feasible.

05Applications

Applications

B2B manufacturing use only — no finished-product or health claims.

Recovery and post-workout powders

Free-form amino acid and EAA blends

Clinical and enteral nutrition

Capsules and tablets

Cell-culture media and biotech fermentation feeds

Gut-health and specialty nutrition formulations

06Regulatory status by market

Regulatory status by market

Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.

Market	Status	Basis
United States	Listed by name in FDA's food-additive regulation for amino acids as 'L-Glutamine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 12.4 (as L-glutamic acid, including L-glutamine) percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111.	21 CFR 172.320(a), (b), (c)(4), (e)
United States (GRAS)	A search of FDA's GRAS Notice Inventory for 'glutamine' returned only an unrelated enzyme-preparation notice (GRN 1289, a protein-glutamine glutaminase). There is no GRAS notice for L-glutamine itself.	FDA GRAS Notice Inventory
European Union	Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice.	Directive 2002/46/EC (food supplements); national member-state rules
Japan	No JP XVIII Official Monograph for L-glutamine was located. L-Glutamine appears in JP XVIII only in the Reagents/Test Solutions section, referenced to JIS K 9103 (L(+)-glutamine, Special class) — a reagent standard, not a pharmacopoeial monograph.	JP XVIII, Reagents, Test Solutions and Standard Solutions
China	Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.	GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements

07Selected research

Selected research

Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.

These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.

A systematic review and meta-analysis of clinical trials in athletes assessed glutamine supplementation against body mass, lean body mass, body-fat percentage, VO2max and lymphocyte, leukocyte and neutrophil counts. Ramezani Ahmadi A, Rayyani E, Bahreini M, Mansoori A. Clin Nutr. 2019;38(3):1076-1091. PMID 29784526 DOI 10.1016/j.clnu.2018.05.001 Source
A review of glutamine metabolism reported that the rate of glutamine consumption by immune cells is similar to or greater than that of glucose, and that glutamine availability is controlled mainly by key metabolic organs. Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Nutrients. 2018;10(11):1564. PMID 30360490 DOI 10.3390/nu10111564 Source
A review of the side effects of amino acid supplements examined glutamine among other amino acids and discussed ammonia production and competition for shared membrane carriers as mechanisms relevant to high intakes. Holeček M. Physiol Res. 2022;71(1):29-45. PMID 35043647 DOI 10.33549/physiolres.934790 Source

08Packing, storage & lead time

Packing, storage & lead time

Standard packing	25 kg bags, cartons or drums
Private packing	Custom packing & labeling available for regular customers
Storage	Cool, dry place, sealed in original packaging
Lead time	Sourced to order — about 1 week to Shanghai port
Shipping	Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane

09Procurement FAQ

Procurement FAQ

01My glutamine concentrate crystallised in the warehouse. Why?

Almost certainly temperature. Glutamine needs 20.8 mL of water per gram at 30 °C but 38.5 mL at 18 °C and 56.7 mL at 0 °C. A solution made at tank temperature can be supersaturated at warehouse temperature. Set your maximum concentration from the coldest point in the distribution chain.

02Is 'FCC' on your offer sheet a real monograph grade?

It is the grade designation the manufacturer uses, and we will send you the specification sheet it refers to. One honest caveat worth knowing: FDA's amino-acid regulation, 21 CFR 172.320, cites Food Chemicals Codex pages for most amino acids but lists L-glutamine under a different reference standard. If your QA needs a named FCC edition and monograph, ask and we will get it confirmed in writing before you order.

03Can I put glutamine in an alcohol-based liquid?

No. It is practically insoluble in ethanol (0.46 mg/100 mL) and methanol (3.5 mg/100 mL). Glutamine is an aqueous-format and dry-blend ingredient only.

04What should be on the COA besides assay?

Ask for ammonium, loss on drying, and heavy metals as a minimum. Ammonium is the row that tells you whether the batch has been held wet or warm, which for glutamine is the failure mode that actually occurs in transit.

05What is the MOQ for L-Glutamine?

MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.

06Can I get a sample of L-Glutamine before ordering?

Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.

10Related