01Product

L-Lysine HCl 82% Lysine

At a glance

L-Lysine HCl from Zhicheng Bio — supply summary

Zhicheng Bio supplies bulk L-Lysine HCl (82% Lysine), CAS 657-27-2, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Sourced to order — about 1 week to Shanghai port. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.

Supplier: Zhicheng Bio, Shanghai, China
CAS number: 657-27-2
Molecular formula: C6H14N2O2·HCl
Grade / specification: 82% Lysine
Availability: Made to order
Documents: Batch CoA with every shipment; spec sheet and MSDS on request
Packing: Bags
PubChem CID: 69568
How to get a price: Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published

Amino Acids ~1 week

L-Lysine HCl

82% Lysine

CAS 657-27-2 · C6H14N2O2·HCl

Bulk L-Lysine HCl for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.

$1.77 – $1.99 /kg by order volume · indicative, ex-Shanghai

Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.

Category: Amino Acids

Availability: Sourced to order — about 1 week to Shanghai port

Packing: Bags

Key supply points

Supplied against your target specification — USP / FCC / JP monograph where applicable
Recent batch COA provided with the quotation, before you commit
Consolidates with other SKUs into one shipment out of Shanghai
Third-party lab verification available pre-shipment on request

Documentation with every batch

COA per batchSpec SheetMSDS / SDSExport docs

Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.

Request COA & Quote Use the RFQ form

Shipping & Lead Time

Estimate freight for this product

~1 weekSourced to order — about 1 week to Shanghai port

Destination region Quantity (kg)

Air FreightFast

Transit: —
Est. freight *: —
Total door-to-port: —

Sea LCLValue

Transit: —
Est. freight *: —
Total door-to-port: —

Request Exact Quote

Documentation-first

COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.

Ready-stock depth

Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.

Certified supply chain

Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.

Flexible export

25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.

02Identity & properties

Identity & properties

Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.

CAS No.	657-27-2
Molecular Formula	C6H15ClN2O2 (written as C6H14N2O2·HCl)
Molecular Weight	182.65
EINECS	211-519-9 (PubChem also lists 233-234-9)
Synonyms	L-Lysine monohydrochloride, L-Lysine HCl, Lysine hydrochloride
Appearance	White or almost white free-flowing crystalline powder
Solubility	Very freely soluble in water — free-base L-lysine exceeds 100 g per 100 g water at 25 °C; insoluble in ethanol, ether, acetone and benzene. Merck reports the monohydrochloride as crystals from dilute ethanol, melting at 263-264 °C when anhydrous.
Pharmacopoeial reference	FCC · JP (as L-Lysine Hydrochloride)

03Specifications

Specifications

Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.

Parameter	Specification	Test method
Stated lysine content	82% (as printed on the offer sheet) — see verify note	Per supplier offer sheet
Assay (as-is / dried basis)	—	Titration or HPLC per the applicable monograph
Appearance	—	Visual
Identification	—	IR / specific optical rotation per monograph
Specific optical rotation	—	Polarimetry
Loss on drying	—	Gravimetric
Residue on ignition / sulphated ash	—	Gravimetric
Chloride	—	Per monograph
Sulphate	—	Per monograph
Iron	—	Per monograph
Other amino acids / related substances	—	TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)	—	ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)	—	USP <61>/<62> or equivalent

A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.

04Formulation & handling notes

Formulation & handling notes

The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.

Lysine is the most water-soluble amino acid on this entire list — the free base exceeds 100 g per 100 g of water at 25 °C. It will never be your solubility bottleneck; it is the one you can load into a concentrate without thinking about it.

That extreme water affinity is also its handling problem. Highly soluble amino acid hydrochlorides pick up moisture readily and can cake in a part-used bag, so this is a bagged item to decant fully and reseal, not to leave open on the line.

The theoretical maximum lysine content of the monohydrochloride is 80.0% (146.19/182.65). The feed and food trade normally states it as '98.5% min L-lysine HCl, equivalent to 78.8% lysine'. Any offer claiming materially more than 80% lysine from a monohydrochloride is either quoting the salt assay or is wrong.

As a diamino acid it carries a second basic amine (pK values reported as 2.18, 8.95 and 10.53 at 38 °C for the free base), so even the hydrochloride sits on the alkaline side of neutral for a salt and will interact with an acidic beverage buffer differently from a monoamino acid hydrochloride.

In Maillard-prone systems — bars, baked inclusions, UHT dairy — the free epsilon-amino group of lysine is the classic reactive site. Lysine fortification of a heat-treated product should be checked for browning and for available-lysine loss, which does not apply to, say, valine or isoleucine.

It is priced as a commodity (this is the lowest-cost SKU in the range), so on large volumes freight and packing format, not the material price, usually determine landed cost.

05Applications

Applications

B2B manufacturing use only — no finished-product or health claims.

Amino acid fortification of cereal-based foods and beverages

Free-form amino acid and EAA blends

Capsules and tablets

Pet-food and animal-nutrition premixes (a high-volume outlet for this SKU)

Clinical and enteral nutrition

06Regulatory status by market

Regulatory status by market

Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.

Market	Status	Basis
United States	Listed by name in FDA's food-additive regulation for amino acids as 'L-Lysine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 6.4 percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111.	21 CFR 172.320(a), (b), (c)(4), (e)
European Union	Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice.	Directive 2002/46/EC (food supplements); national member-state rules
Japan	An Official Monograph titled 'L-Lysine Hydrochloride' is listed in the Japanese Pharmacopoeia, Eighteenth Edition. Monograph existence only — no limits transcribed.	JP XVIII, Official Monographs
China	Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.	GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements

07Selected research

Selected research

Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.

These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.

A systematic review of 71 intervention studies (3,357 subjects, doses to 17.5 g/day, dosing periods to 1,095 days) reported that observed adverse events were mainly subjective gastrointestinal symptoms, with a risk ratio of 1.02 that was not statistically significant, and identified a provisional no-observed-adverse-effect level of 6.0 g/day. Hayamizu K, Oshima I, Nakano M. J Nutr. 2020;150(Suppl 1):2561S-2569S. PMID 33000161 DOI 10.1093/jn/nxaa218 Source
A review examined the overall effectiveness of lysine supplementation for growth in children and adolescents, noting its long use in populations whose staple diets are cereal-based, and set out precautions. Gunarathne R, Guan X, Feng T, Zhao Y, Lu J. J Adv Res. 2025;70:571-586. PMID 38740261 DOI 10.1016/j.jare.2024.05.014 Source
A systematic review found that lysine supplementation was not effective for the prevention or treatment of feline herpesvirus 1 infection in cats. Bol S, Bunnik EM. BMC Vet Res. 2015;11:284. PMID 26573523 DOI 10.1186/s12917-015-0594-3 Source

08Packing, storage & lead time

Packing, storage & lead time

Standard packing	Bags
Private packing	Custom packing & labeling available for regular customers
Storage	Cool, dry place, sealed in original packaging
Lead time	Sourced to order — about 1 week to Shanghai port
Shipping	Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane

09Procurement FAQ

Procurement FAQ

01Your sheet says 82% lysine. Is that achievable?

No, and we would rather tell you now. The theoretical maximum for L-lysine monohydrochloride is 80.0% lysine (146.19/182.65), and the trade convention is 98.5% min salt, equal to about 78.8% lysine. Ask us for the manufacturer's specification sheet and we will have the basis restated correctly before you order — the number matters if you are calculating a fortification rate.

02Is this food grade or feed grade?

Tell us which you need in the RFQ, because they are different specifications from different plants even though both are 'L-lysine HCl'. Feed grade is a very large market and can be cheaper; it will not carry the microbiological and heavy-metal limits a food or supplement customer needs.

03Will lysine cause browning in my bar or UHT drink?

It can. Lysine's free epsilon-amino group is the classic Maillard reactant, so a lysine-fortified heat-treated product should be run through a browning and available-lysine check. This is not an issue with the branched-chain amino acids.

04How is it packed?

Bagged as standard for this SKU. Because lysine HCl is very hygroscopic, decant whole bags rather than part-using them, and reseal immediately — caking in a half-empty bag is the most common complaint we see on this item.

05What is the MOQ for L-Lysine HCl?

MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.

06Can I get a sample of L-Lysine HCl before ordering?

Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.

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