ZHICHENG BIO
Sports NutritionIn stock
L-Citrulline Malate 2:1
2:1
$5.02 – $5.62 /kgby order volume
01Product
L-Citrulline
At a glance
L-Citrulline from Zhicheng Bio — supply summary
Zhicheng Bio supplies bulk L-Citrulline, CAS 372-75-8, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Sourced to order — about 1 week to Shanghai port. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.
- Supplier
- Zhicheng Bio, Shanghai, China
- CAS number
- 372-75-8
- Molecular formula
- C6H13N3O3
- Availability
- Made to order
- Documents
- Batch CoA with every shipment; spec sheet and MSDS on request
- Packing
- 25 kg cartons or bags, adjustable
- PubChem CID
- 9750
- How to get a price
- Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published
Sports Nutrition
~1 week
L-Citrulline
CAS 372-75-8 · C6H13N3O3
Bulk L-Citrulline for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.
$6.06 – $6.78 /kg
by order volume · indicative, ex-Shanghai
Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.
Key supply points
- Supplied against your target specification — USP / FCC / JP monograph where applicable
- Recent batch COA provided with the quotation, before you commit
- Consolidates with other SKUs into one shipment out of Shanghai
- Third-party lab verification available pre-shipment on request
Documentation with every batch
COA per batchSpec SheetMSDS / SDSExport docs
Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.
Shipping & Lead Time
Estimate freight for this product
~1 weekSourced to order — about 1 week to Shanghai port
Air FreightFast
- Transit
- —
- Est. freight *
- —
- Total door-to-port
- —
Sea LCLValue
- Transit
- —
- Est. freight *
- —
- Total door-to-port
- —
Documentation-first
COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.
Ready-stock depth
Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.
Certified supply chain
Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.
Flexible export
25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.
02Identity & properties
Identity & properties
Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.
| CAS No. | 372-75-8 |
|---|---|
| Molecular Formula | C6H13N3O3 |
| Molecular Weight | 175.19 |
| EINECS | 206-759-6 |
| Synonyms | L-Citrulline, Cit, (2S)-2-amino-5-(carbamoylamino)pentanoic acid, 2-amino-5-ureidopentanoic acid |
| Appearance | White crystalline powder |
| Solubility | Water 200 g/L at 20 °C (also reported as 212 mg/mL) |
03Specifications
Specifications
Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.
| Parameter | Specification | Test method |
|---|---|---|
| Assay (as-is / dried basis) | — | Titration or HPLC per the applicable monograph |
| Appearance | — | Visual |
| Identification | — | IR / specific optical rotation per monograph |
| Specific optical rotation | — | Polarimetry |
| Loss on drying | — | Gravimetric |
| Residue on ignition / sulphated ash | — | Gravimetric |
| Chloride | — | Per monograph |
| Sulphate | — | Per monograph |
| Iron | — | Per monograph |
| Other amino acids / related substances | — | TLC or HPLC per monograph |
| Heavy metals (Pb / As / Cd / Hg) | — | ICP-MS or per monograph |
| Microbiology (TAMC / TYMC / E. coli / Salmonella) | — | USP <61>/<62> or equivalent |
A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.
04Formulation & handling notes
Formulation & handling notes
The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.
01
At 200 g/L in water at 20 °C, free citrulline is roughly five times more soluble than L-leucine and more than four hundred times more soluble than L-tyrosine — it is one of the easiest amino acids on this list to get into solution, and it will not be the limiting ingredient in a concentrated shot.
02
It is close to neutral in solution (reported pKa 2.43 for the carboxyl group; no strongly basic guanidino group like arginine's), so unlike arginine base it will not push the pH of a formulated drink around, and unlike citrulline malate it will not pull it down.
03
Free citrulline is 100% citrulline by definition, against 72.3% for the 2:1 malate and 56.6% for the 1:1 salt. A gram-for-gram substitution between the free amino acid and any malate grade will silently change the citrulline dose on the label.
04
Melting point is reported at 235.5 °C, and like the other amino acids here it decomposes rather than melting cleanly — keep it out of hot-melt and high-temperature extrusion steps.
05
Watch for L-ornithine and urea as the process-related impurities of interest in citrulline made by fermentation; ask for the manufacturer's limits on related substances rather than accepting a bare assay figure.
05Applications
Applications
B2B manufacturing use only — no finished-product or health claims.
Pre-workout and nitric-oxide-precursor blends
Ready-to-drink and ready-to-mix sports beverages
Capsules and tablets
Endurance and recovery formulations
Clinical and medical nutrition blends
06Regulatory status by market
Regulatory status by market
Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.
| Market | Status | Basis |
|---|---|---|
| United States | A search of FDA's GRAS Notice Inventory for 'citrulline' returned zero records, and citrulline is not among the amino acids listed in 21 CFR 172.320. US marketing rests on DSHEA rather than on an FDA food-ingredient clearance. | FDA GRAS Notice Inventory (0 records); 21 CFR 172.320 |
| European Union | Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice. | Directive 2002/46/EC (food supplements); national member-state rules |
| China | Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed. | GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements |
| Japan | No JP XVIII Official Monograph for this substance was located. | JP XVIII |
07Selected research
Selected research
Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.
These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.
- A systematic review and meta-analysis of acute citrulline supplementation reported on high-intensity strength and power outcomes across the available randomised trials. Trexler ET, Persky AM, Ryan ED, Schwartz TA, Stoner L, Smith-Ryan AE. Sports Med. 2019;49(5):707-718. PMID 30895562DOI 10.1007/s40279-019-01091-zSource
- A systematic review and meta-analysis of randomised controlled trials examined whether acute citrulline ingestion affects time-to-completion and time-to-exhaustion endurance outcomes in young healthy adults, noting that findings in this literature have been inconsistent. Harnden CS, Agu J, Gascoyne T. J Int Soc Sports Nutr. 2023;20(1):2209056. PMID 37155582DOI 10.1080/15502783.2023.2209056Source
- A review of the citrulline literature reported that oral L-citrulline and citrulline malate supplementation increase plasma citrulline and arginine concentrations along with total nitrate and nitrite concentrations. Gonzalez AM, Trexler ET. J Strength Cond Res. 2020;34(5):1480-1495. PMID 31977835DOI 10.1519/JSC.0000000000003426Source
- A systematic review and meta-analysis assessed citrulline supplementation across aerobic exercise performance outcomes including lactate, oxygen-uptake kinetics and rating of perceived exertion. Viribay A, Fernández-Landa J, Castañeda-Babarro A, Collado PS, Fernández-Lázaro D, Mielgo-Ayuso J. Nutrients. 2022;14(17):3479. PMID 36079738DOI 10.3390/nu14173479Source
08Packing, storage & lead time
Packing, storage & lead time
| Standard packing | 25 kg bags, cartons or drums |
|---|---|
| Private packing | Custom packing & labeling available for regular customers |
| Storage | Cool, dry place, sealed in original packaging |
| Lead time | Sourced to order — about 1 week to Shanghai port |
| Shipping | Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane |
09Procurement FAQ
Procurement FAQ
01How concentrated a citrulline solution can I make?
Free L-citrulline dissolves at 200 g/L in water at 20 °C, so a 6-8 g serving in a 60 mL shot is comfortably inside its solubility. It is rarely the ingredient that limits a concentrate.
02Free citrulline or citrulline malate for a beverage?
Free citrulline is near-neutral and gives you 100% citrulline per gram; malate is acidic and gives 72% at 2:1. If your flavour system is citrus and you want the tartness anyway, malate does double duty. If you are dosing to a citrulline number and want pH control, use the free form.
03Which impurities should I be specifying?
Ask for limits on L-ornithine, urea and total related substances, not just assay. These are the fermentation-route markers your QA will be asked about in an audit. We will request the manufacturer's own limits and put them in the specification sheet.
04How much can you ship, and how fast?
This is one of our deepest positions — around 11 tonnes available, roughly one week to Shanghai. It consolidates in the same container as citrulline malate, creatine and carnitine tartrate.
05What is the MOQ for L-Citrulline?
MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.
06Can I get a sample of L-Citrulline before ordering?
Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.
10Related
You may also need
Sports Nutrition~1 week
Agmatine Sulfate 99%
57% Agmatine
$7.98 – $8.93 /kgby order volume
Sports NutritionIn stock
Arginine Nitrate
73% L-Arginine / 27% Nitrate
$6.79 – $7.61 /kgby order volume