01Product

L-Citrulline Malate 2:1 2:1

At a glance

L-Citrulline Malate 2:1 from Zhicheng Bio — supply summary

Zhicheng Bio supplies bulk L-Citrulline Malate 2:1 (2:1), CAS 54940-97-5, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.

Supplier: Zhicheng Bio, Shanghai, China
CAS number: 54940-97-5
Molecular formula: 2(C6H13N3O3)·C4H6O5
Grade / specification: 2:1
Availability: Made to order
Documents: Batch CoA with every shipment; spec sheet and MSDS on request
Packing: 25 kg cartons or bags, adjustable
PubChem CID: 162762
How to get a price: Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published

Sports Nutrition In stock

L-Citrulline Malate 2:1

2:1

CAS 54940-97-5 · 2(C6H13N3O3)·C4H6O5

Bulk L-Citrulline Malate 2:1 for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.

$5.02 – $5.62 /kg by order volume · indicative, ex-Shanghai

Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.

Category: Sports Nutrition

Availability: In stock

Packing: 25 kg bags, cartons or drums (standard)

Key supply points

Supplied against your target specification — USP / FCC / JP monograph where applicable
Recent batch COA provided with the quotation, before you commit
Consolidates with other SKUs into one shipment out of Shanghai
Third-party lab verification available pre-shipment on request

Documentation with every batch

COA per batchSpec SheetMSDS / SDSExport docs

Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.

Request COA & Quote Use the RFQ form

Shipping & Lead Time

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Documentation-first

COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.

Ready-stock depth

Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.

Certified supply chain

Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.

Flexible export

25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.

02Identity & properties

Identity & properties

Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.

CAS No.	54940-97-5 (as supplied on the offer sheet)
Molecular Formula	2(C6H13N3O3)·C4H6O5
Molecular Weight	484.47 (2:1, by summation) — PubChem gives 309.27 for the 1:1 salt
EINECS	927-830-4, 812-225-9 or 976-200-5
Synonyms	Citrulline malate, CitMal, L-citrulline DL-malate, CM 2:1
Appearance	White to off-white crystalline powder
Solubility	Freely soluble in water

03Specifications

Specifications

Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.

Parameter	Specification	Test method
L-Citrulline content	—	HPLC
Malic acid content	—	HPLC or titration
Ratio (citrulline:malate)	2:1	Per specification
Assay (as-is / dried basis)	—	Titration or HPLC per the applicable monograph
Appearance	—	Visual
Identification	—	IR / specific optical rotation per monograph
Specific optical rotation	—	Polarimetry
Loss on drying	—	Gravimetric
Residue on ignition / sulphated ash	—	Gravimetric
Chloride	—	Per monograph
Sulphate	—	Per monograph
Iron	—	Per monograph
Other amino acids / related substances	—	TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)	—	ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)	—	USP <61>/<62> or equivalent

A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.

04Formulation & handling notes

Formulation & handling notes

The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.

The single most important thing to get right on this ingredient is the ratio, because it changes the citrulline you are actually buying. In a 2:1 composition citrulline is 72.3% of the mass; in a 1:1 salt it is 56.6%. An 8 g 'citrulline malate' dose therefore delivers either 5.8 g or 4.5 g of citrulline depending on which grade landed in the blender.

There is a CAS trap here that catches even experienced buyers. CAS 54940-97-5 corresponds to the 1:1 salt (C10H19N3O8, MW 309.27 in PubChem), yet the whole sports-nutrition trade prints it on 2:1 documentation. Write the ratio next to the CAS on your specification so an auditor cannot read the CAS as a stoichiometry claim.

Malic acid is what makes this form work in beverages: it brings sourness and a sharply lower solution pH than free citrulline, which is exactly why RTD and effervescent formats choose the malate over the free amino acid — and also why it needs a citrus or berry flavour system rather than a creamy one.

The malate load has to be counted in your total acid budget. At an 8 g dose the 2:1 grade contributes roughly 2.2 g of malic acid, which is enough to move the pH and titratable acidity of an unbuffered drink on its own.

The malic acid in commercial citrulline malate is usually DL-malic acid, not L-malic. If your label, your organic certification or your destination market cares about that distinction, ask for it in writing — it is rarely stated unless requested.

05Applications

Applications

B2B manufacturing use only — no finished-product or health claims.

Pre-workout powders (the highest-volume use of this ingredient)

Ready-to-drink and ready-to-mix sports beverages

Effervescent tablets and stick packs

Endurance and pump-focused blends

Flavoured amino acid drinks

06Regulatory status by market

Regulatory status by market

Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.

Market	Status	Basis
United States	A search of FDA's GRAS Notice Inventory for 'citrulline' returned zero records — there is no GRAS notice for L-citrulline or citrulline malate. Citrulline is also not among the amino acids listed in 21 CFR 172.320. US marketing therefore rests on dietary supplement law (DSHEA) rather than on any FDA food-ingredient clearance.	FDA GRAS Notice Inventory (0 records for 'citrulline'); 21 CFR 172.320
European Union	Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice.	Directive 2002/46/EC (food supplements); national member-state rules
China	Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.	GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements
Japan	No JP XVIII Official Monograph for this substance was located.	JP XVIII

07Selected research

Selected research

Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.

These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.

A critical review of citrulline malate and exercise performance noted that a single acute 8 g dose has been the most common protocol and that results across resistance-exercise and cycling studies have been equivocal. Gough LA, Sparks SA, McNaughton LR, Higgins MF, Newbury JW, Trexler E, Faghy MA, Bridge CA. Eur J Appl Physiol. 2021;121(12):3283-3295. PMID 34417881 DOI 10.1007/s00421-021-04774-6 Source
A meta-analysis of four randomised controlled trials (138 assessments) in resistance-trained adults did not observe an overall effect of citrulline malate supplementation favouring citrulline malate on muscle strength outcomes. Aguiar AF, Casonatto J. J Diet Suppl. 2022;19(6):772-790. PMID 34176406 DOI 10.1080/19390211.2021.1939473 Source
A six-week double-blind placebo-controlled trial in 33 resistance-trained men compared 8 g/day L-citrulline with 12 g/day L-citrulline DL-malate and placebo, and reported significant differences from placebo for total upper-body repetitions to failure in both active arms. Bayat D, Azizi M, Behpour N, Tinsley GM. J Int Soc Sports Nutr. 2025;22(1):2513944. PMID 40470618 DOI 10.1080/15502783.2025.2513944 Source
A systematic review and three-level meta-analysis examined the effects of citrulline malate supplementation across exercise-performance outcomes. Wang X, Fan X, Chang J, et al. Nutrients. 2026;18(12):1881. PMID 42356270 DOI 10.3390/nu18121881 Source

08Packing, storage & lead time

Packing, storage & lead time

Standard packing	25 kg bags, cartons or drums
Private packing	Custom packing & labeling available for regular customers
Storage	Cool, dry place, sealed in original packaging
Lead time	In stock
Shipping	Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane

09Procurement FAQ

Procurement FAQ

01Is this genuinely 2:1, and how do I verify it?

It is supplied as the 2:1 grade. Verify it the way an auditor would: ask for the batch COA showing citrulline and malic acid assayed separately. A true 2:1 sits near 72% citrulline and 28% malic acid; a 1:1 salt sits near 57% and 43%. The two assays together are the only proof of ratio.

02Why does the CAS number point to a 1:1 salt?

Because CAS 54940-97-5 was assigned to citrulline malate as a 1:1 salt, while the sports-nutrition market standardised on the 2:1 ratio and kept using the same CAS. It is an industry-wide inconsistency, not a defect in this lot. We recommend writing 'CAS 54940-97-5 (citrulline malate), supplied at 2:1 ratio' on your own specification so nobody reads the CAS as a stoichiometry claim.

03Should I buy citrulline malate or free L-citrulline?

Free citrulline if you want the highest citrulline per gram and a neutral taste; malate if you want a beverage-friendly acidic form and are happy to carry the malic acid. We stock both, so send us your target citrulline per serving and we will quote the cheaper route to it.

04Is the malic acid L- or DL-?

Commercial citrulline malate normally uses DL-malic acid. If your label or your destination market needs L-malic specifically, say so in the RFQ — we will get it confirmed in writing by the manufacturer rather than assumed.

05What is the MOQ for L-Citrulline Malate 2:1?

MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.

06Can I get a sample of L-Citrulline Malate 2:1 before ordering?

Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.

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