01Product

Agmatine Sulfate 99% 57% Agmatine

At a glance

Agmatine Sulfate 99% from Zhicheng Bio — supply summary

Zhicheng Bio supplies bulk Agmatine Sulfate 99% (57% Agmatine), CAS 2482-00-0, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Sourced to order — about 1 week to Shanghai port. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.

Supplier: Zhicheng Bio, Shanghai, China
CAS number: 2482-00-0
Molecular formula: C5H14N4·H2SO4
Grade / specification: 57% Agmatine
Availability: Made to order
Documents: Batch CoA with every shipment; spec sheet and MSDS on request
Packing: 25 kg cartons or bags, adjustable
PubChem CID: 2794990
How to get a price: Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published

Sports Nutrition ~1 week

Agmatine Sulfate 99%

57% Agmatine

CAS 2482-00-0 · C5H14N4·H2SO4

Bulk Agmatine Sulfate 99% for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.

$7.98 – $8.93 /kg by order volume · indicative, ex-Shanghai

Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.

Category: Sports Nutrition

Availability: Sourced to order — about 1 week to Shanghai port

Packing: 25 kg bags, cartons or drums (standard)

Key supply points

Supplied against your target specification — USP / FCC / JP monograph where applicable
Recent batch COA provided with the quotation, before you commit
Consolidates with other SKUs into one shipment out of Shanghai
Third-party lab verification available pre-shipment on request

Documentation with every batch

COA per batchSpec SheetMSDS / SDSExport docs

Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.

Request COA & Quote Use the RFQ form

Shipping & Lead Time

Estimate freight for this product

~1 weekSourced to order — about 1 week to Shanghai port

Destination region Quantity (kg)

Air FreightFast

Transit: —
Est. freight *: —
Total door-to-port: —

Sea LCLValue

Transit: —
Est. freight *: —
Total door-to-port: —

Request Exact Quote

Documentation-first

COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.

Ready-stock depth

Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.

Certified supply chain

Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.

Flexible export

25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.

02Identity & properties

Identity & properties

Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.

CAS No.	2482-00-0
Molecular Formula	C5H16N4O4S (written as C5H14N4·H2SO4)
Molecular Weight	228.27
EINECS	219-617-3
Synonyms	Agmatine sulphate, 4-aminobutylguanidine sulfate, decarboxylated arginine sulfate, 1-amino-4-guanidinobutane sulfate
Appearance	White to off-white crystalline powder
Solubility	Freely soluble in water

03Specifications

Specifications

Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.

Parameter	Specification	Test method
Assay (agmatine sulfate)	99% (as offered) — confirm basis and method	HPLC (to be confirmed)
Agmatine content (free base equivalent)	57.0% theoretical	Calculated from molecular weights
Sulfate	—	Per specification
Related substances (arginine, guanidine)	—	HPLC
Assay (as-is / dried basis)	—	Titration or HPLC per the applicable monograph
Appearance	—	Visual
Identification	—	IR / specific optical rotation per monograph
Specific optical rotation	—	Polarimetry
Loss on drying	—	Gravimetric
Residue on ignition / sulphated ash	—	Gravimetric
Chloride	—	Per monograph
Sulphate	—	Per monograph
Iron	—	Per monograph
Other amino acids / related substances	—	TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)	—	ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)	—	USP <61>/<62> or equivalent

A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.

04Formulation & handling notes

Formulation & handling notes

The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.

Agmatine is decarboxylated arginine — chemically it is what you get when arginine loses its carboxyl group — and that has a direct analytical consequence: residual arginine is the process-related impurity to specify, and an amino-acid method tuned for arginine may not resolve agmatine cleanly. Ask for an agmatine-specific HPLC method.

The 57% agmatine figure is stoichiometrically exact, not a marketing number: agmatine free base is 130.19 in a 228.27 g/mol sulfate salt, which is 57.03%. A '1000 mg agmatine sulfate' serving delivers 570 mg of agmatine. Label the salt or the base, but never let the two be confused.

It is a guanidinium salt with a strongly basic guanidine group, so the sulfate salt is what makes it a handleable solid at all — and the sulfate load (43% of the mass) has to be counted in a formula's total sulfate and mineral budget.

The taste is the practical formulation obstacle: guanidinium compounds are characteristically bitter and unpleasant, which is why agmatine appears in capsules far more often than in flavoured powders. Bench-test the flavour system before committing to a stick pack.

This is the one product in the Zhicheng Bio range where the regulatory question is more important than the technical one. It has no pharmacopoeial monograph, no GRAS notice, no place in 21 CFR 172.320 and no identified EU novel-food authorisation. Sell it on documentation and honesty about status, never on implied compliance.

05Applications

Applications

B2B manufacturing use only — no finished-product or health claims.

Pre-workout and pump-focused formulations

Capsules and stick packs

Research and analytical reference use

Combination products with citrulline and arginine

06Regulatory status by market

Regulatory status by market

Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.

Market	Status	Basis
United States	Agmatine is not among the amino acids listed in 21 CFR 172.320 and no GRAS notice for agmatine was identified. Its status as a lawful dietary ingredient in the US has been the subject of industry debate (the question being whether it qualifies as a dietary ingredient at all, and if so whether a New Dietary Ingredient notification is required).	21 CFR 172.320; DSHEA / New Dietary Ingredient framework
European Union	Agmatine sulfate is very likely to require novel-food authorisation for food or supplement use in the EU; no authorisation was identified.	Regulation (EU) 2015/2283 (novel foods)
China	Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.	GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements
Japan	No JP XVIII Official Monograph for this substance was located.	JP XVIII

07Selected research

Selected research

Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.

These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.

A review co-authored by sixteen research groups summarised the preclinical and initial clinical evidence on agmatine, describing it as decarboxylated arginine with modulatory action at multiple molecular targets including neurotransmitter systems, nitric oxide synthesis and polyamine metabolism, and highlighting that its biosynthesis in mammals was only demonstrated relatively recently. Piletz JE, Aricioglu F, Cheng JT, et al. Drug Discov Today. 2013;18(17-18):880-893. PMID 23769988 DOI 10.1016/j.drudis.2013.05.017 Source
A review of agmatine reported that the neuroprotective effects described in the literature have been observed in CNS cell lines and animal models rather than in human trials. Kotagale NR, Taksande BG, Inamdar NN. Neurotoxicology. 2019;73:228-245. PMID 31063707 DOI 10.1016/j.neuro.2019.05.001 Source
A review discussed agmatine as an endogenous ligand at imidazoline receptors and as a possible neurotransmitter in brain. Reis DJ, Regunathan S. J Auton Nerv Syst. 1998;72(2-3):80-85. PMID 9851555 DOI 10.1016/s0165-1838(98)00091-5 Source

08Packing, storage & lead time

Packing, storage & lead time

Standard packing	25 kg bags, cartons or drums
Private packing	Custom packing & labeling available for regular customers
Storage	Cool, dry place, sealed in original packaging
Lead time	Sourced to order — about 1 week to Shanghai port
Shipping	Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane

09Procurement FAQ

Procurement FAQ

01How much agmatine is in agmatine sulfate?

57.0%, exactly — agmatine free base is 130.19 g/mol in a 228.27 g/mol sulfate salt. So 1000 mg of agmatine sulfate is 570 mg of agmatine. Decide which one your label declares and state it in the RFQ; this is the most common source of error on this ingredient.

02What is the regulatory status of agmatine in my market?

This is the honest answer: we cannot tell you, and you should not accept a supplier who says they can. Agmatine is not listed in FDA's amino-acid regulation, has no GRAS notice, and we found no EU novel-food authorisation. Its US dietary-ingredient status has been debated in the industry. Take it to your own regulatory counsel before you formulate. We will supply full manufacturer documentation to support whatever assessment they make.

03Which impurities matter on agmatine sulfate?

Residual arginine above all — agmatine is made by decarboxylating arginine — plus guanidine-type related substances and the sulfate assay itself. There is no monograph for this material, so the manufacturer's own method and limits are all there is. We will get them in writing.

04Will it work in a flavoured powder?

Test it first. Guanidinium salts are characteristically bitter, which is why agmatine usually ends up in capsules. Ask us for a sample and taste it in your actual flavour system before you commit to a stick-pack format.

05What is the MOQ for Agmatine Sulfate 99%?

MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.

06Can I get a sample of Agmatine Sulfate 99% before ordering?

Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.

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