01Product

L-Valine

At a glance

L-Valine from Zhicheng Bio — supply summary

Zhicheng Bio supplies bulk L-Valine, CAS 72-18-4, shipping from Shanghai, China. This grade is produced to order. Every shipment carries a batch Certificate of Analysis; specification sheet and MSDS are supplied on request. Zhicheng Bio publishes no list price — quotes are issued per quantity and Incoterm by email to zhicheng1@zhicheng-bio.cn.

Supplier: Zhicheng Bio, Shanghai, China
CAS number: 72-18-4
Molecular formula: C5H11NO2
Availability: Made to order
Documents: Batch CoA with every shipment; spec sheet and MSDS on request
Packing: 25 kg cartons or bags, adjustable
PubChem CID: 6287
How to get a price: Email RFQ to zhicheng1@zhicheng-bio.cn — no list price is published

BCAA / EAA In stock

L-Valine

CAS 72-18-4 · C5H11NO2

Bulk L-Valine for B2B manufacturing — supplied against your target specification, with documentation your QA can review before anything ships. Pricing below is indicative; send an RFQ for a firm quote, MOQ and lead time.

$3.40 – $3.81 /kg by order volume · indicative, ex-Shanghai

Indicative range — larger volumes price toward the low end. Ingredient markets move weekly; your firm price is confirmed by quotation, typically within one business day.

Category: BCAA / EAA

Availability: In stock

Packing: 25 kg bags, cartons or drums (standard)

Key supply points

Supplied against your target specification — USP / FCC / JP monograph where applicable
Recent batch COA provided with the quotation, before you commit
Consolidates with other SKUs into one shipment out of Shanghai
Third-party lab verification available pre-shipment on request

Documentation with every batch

COA per batchSpec SheetMSDS / SDSExport docs

Third-party lab verification can be arranged pre-shipment on request. Certificates of origin, non-GMO or allergen statements per destination-market requirements.

Request COA & Quote Use the RFQ form

Shipping & Lead Time

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In stock

Destination region Quantity (kg)

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Documentation-first

COA per batch, Spec Sheet and MSDS — reviewed by your QA before anything ships.

Ready-stock depth

Multi-tonne inventory on core SKUs, plus 28 actives held in our US warehouse in Los Angeles for domestic delivery.

Certified supply chain

Sourced from audited, certified manufacturers — ISO, HACCP, Halal & Kosher available.

Flexible export

25 kg bags, cartons or drums; FOB / CIF / DDP by lane, sea or air consolidation.

02Identity & properties

Identity & properties

Compound identifiers and physical properties for this material. The binding version is always the Specification Sheet and batch COA issued with your quotation.

CAS No.	72-18-4
Molecular Formula	C5H11NO2
Molecular Weight	117.15
EINECS	200-773-6
Synonyms	L-Valine, L-Val, V, (2S)-2-amino-3-methylbutanoic acid
Appearance	White crystalline powder or leaflets
Solubility	Water 88.5 g/L at 25 °C (Merck series: 83.4 g/L at 0 °C, 88.5 at 25 °C, 96.2 at 50 °C, 102.4 at 65 °C; Yalkowsky reports 58.5 g/L at 25 °C). Very slightly soluble in alcohol; insoluble in ether; the Merck Index describes it as insoluble in common neutral solvents.
Pharmacopoeial reference	FCC · JP

03Specifications

Specifications

Typical parameters below — the binding version is the Specification Sheet and batch COA we send with your quotation.

Parameter	Specification	Test method
Assay (as-is / dried basis)	—	Titration or HPLC per the applicable monograph
Appearance	—	Visual
Identification	—	IR / specific optical rotation per monograph
Specific optical rotation	—	Polarimetry
Loss on drying	—	Gravimetric
Residue on ignition / sulphated ash	—	Gravimetric
Chloride	—	Per monograph
Sulphate	—	Per monograph
Iron	—	Per monograph
Other amino acids / related substances	—	TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)	—	ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)	—	USP <61>/<62> or equivalent

A dash means we have no fixed limit to publish for that parameter: it is reported on the batch COA and the limit is agreed with your QA. We would rather leave it blank than invent a number. Full physical, chemical, heavy-metal and microbiological parameters are listed in the Specification Sheet — sent with every quotation.

04Formulation & handling notes

Formulation & handling notes

The practical points our technical team raises with buyers of this material — the things that decide whether a batch behaves in your process.

Valine is by a wide margin the most soluble of the three BCAAs — 88.5 g/L in water at 25 °C against isoleucine's 41.2 and leucine's 24.3. In a 2:1:1 blend it is never the ingredient that limits your concentration, which is worth knowing when you are diagnosing a hazy BCAA drink: the problem is leucine first, isoleucine second, and essentially never valine.

Its solubility is also the flattest with temperature of the three — 83.4 g/L at 0 °C to 102.4 g/L at 65 °C, only about a 23% swing. That makes valine the most predictable BCAA across a cold chain, whereas isoleucine roughly doubles over the same kind of range.

Valine sublimes without melting at ordinary heating rates and decomposes near 298-315 °C in a closed capillary. Sublimation matters for vacuum drying and lyophilisation, where you can lose material to the condenser rather than to degradation.

It is insoluble in common neutral solvents and only very slightly soluble in alcohol, so like the other BCAAs it is aqueous and dry-blend only.

Valine and leucine share the branched-chain pattern but differ in molecular weight (117.15 versus 131.17), so a 2:1:1 blend by weight is not a 2:1:1 blend by moles. If you are specifying a ratio, state whether it is w/w — the industry convention is by weight, but say so.

Reported crystal density is 1.23 g/cm3 at 25 °C. As with the other amino acids in the range, ask for bulk and tapped density separately if you scoop-fill; the crystal figure will overstate what fits in a scoop.

05Applications

Applications

B2B manufacturing use only — no finished-product or health claims.

BCAA 2:1:1 and 4:1:1 blends

EAA and free-form amino acid powders

Intra-workout beverages

Clinical and enteral nutrition

Capsules and tablets

06Regulatory status by market

Regulatory status by market

Status of the raw material, stated as conservatively as our sources allow. This is supply-chain information, not regulatory advice — confirm the position for your finished product and destination market with your own regulatory counsel.

Market	Status	Basis
United States	Listed by name in FDA's food-additive regulation for amino acids as 'L-Valine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 7.4 percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111.	21 CFR 172.320(a), (b), (c)(4), (e)
European Union	Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice.	Directive 2002/46/EC (food supplements); national member-state rules
Japan	An Official Monograph titled 'L-Valine' is listed in the Japanese Pharmacopoeia, Eighteenth Edition. Monograph existence only — no limits transcribed.	JP XVIII, Official Monographs
China	Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.	GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements

07Selected research

Selected research

Peer-reviewed literature on this compound, with linked identifiers so you can read the primary source rather than take our word for it.

These references are listed for scientific context only. They describe published research on the compound; they are not claims about this raw material and not claims about any finished product. Zhicheng Bio makes no medical, health or performance claims.

In rats given an oral glucose tolerance test, valine significantly increased plasma glucose at 30 minutes after the glucose load whereas isoleucine reduced it, and 1 mM valine caused no significant change in glucose consumption in C2C12 myotubes. Doi M, Yamaoka I, Fukunaga T, Nakayama M. Biochem Biophys Res Commun. 2003;312(4):1111-1117. PMID 14651987 DOI 10.1016/j.bbrc.2003.11.039 Source
A systematic review of oral branched-chain amino acid supplementation in athletes assessed the trials available and reported that the evidence base in athletic populations is not clear. Martinho DV, Nobari H, Faria A, Field A, Duarte D, Sarmento H. Nutrients. 2022;14(19):4002. PMID 36235655 DOI 10.3390/nu14194002 Source
A biochemical review examined the evidence for and against an anabolic effect of isolated branched-chain amino acid intake, comprising valine, leucine and isoleucine, on muscle protein synthesis in humans. Santos CS, Nascimento FEL. Einstein (Sao Paulo). 2019;17(3):eRB4898. PMID 31508659 DOI 10.31744/einstein_journal/2019RB4898 Source

08Packing, storage & lead time

Packing, storage & lead time

Standard packing	25 kg bags, cartons or drums
Private packing	Custom packing & labeling available for regular customers
Storage	Cool, dry place, sealed in original packaging
Lead time	In stock
Shipping	Sea or air consolidation out of Shanghai · FOB / CIF / DDP by lane

09Procurement FAQ

Procurement FAQ

01Is valine ever the cause of a cloudy BCAA drink?

Almost never. At 88.5 g/L in water at 25 °C it is over three times more soluble than leucine. If your 2:1:1 blend hazes, look at leucine first and isoleucine second.

02Does a 2:1:1 ratio mean by weight or by moles?

By weight, in industry practice — and it is worth writing 'w/w' on your specification, because the three BCAAs have different molecular weights (leucine and isoleucine 131.17, valine 117.15), so a weight ratio is not a mole ratio.

03We lyophilise our premix. Any concern with valine?

Yes — valine sublimes without melting at ordinary heating rates. Under vacuum you can lose active to the condenser. If your mass balance is off after drying, check there before assuming degradation.

04Stock and lead time?

This is a small ready-stock item (about 50 kg). Larger volumes are procured to order, typically about one week to Shanghai — worth consolidating with leucine and isoleucine so the whole BCAA set ships together.

05What is the MOQ for L-Valine?

MOQ is quote-based and flexible. Tell us your target quantity in the RFQ — for core in-stock SKUs we can usually accommodate both trial orders and multi-tonne volumes.

06Can I get a sample of L-Valine before ordering?

Yes — samples are available on request for evaluation and lab verification. Mention it in your RFQ and we will confirm the arrangement.

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