ZHICHENG BIO
BCAA / EAAundefined
L-Isoleucine
¥40 – ¥44.8 /kg按采购量
01产品详情
L-Leucine
速览
L-Leucine —— 致诚生物供货速览
致诚生物（Zhicheng Bio）从中国上海供应L-Leucine，CAS 61-90-5，非现货，按单排产，每批次随货提供 COA，可另附规格书与 MSDS。按单备货——约1周到上海。询盘请发 zhicheng1@zhicheng-bio.cn，官网不挂价，报价按数量与交货条款单独出。
- 供应商
- 致诚生物 Zhicheng Bio，上海
- CAS 号
- 61-90-5
- 分子式
- C6H13NO2
- 现货状态
- 按单排产
- 随货文件
- 批次 COA；规格书、MSDS 可索取
- 包装
- 25 kg 纸箱/袋，可按需调整
- PubChem CID
- 6106
- 报价方式
- 邮件询盘（zhicheng1@zhicheng-bio.cn），官网不展示价格
BCAA / EAA
约1周
L-Leucine
CAS 61-90-5 · C6H13NO2
L-Leucine 大宗原料，仅面向 B2B 生产采购——按您的目标规格供货，发货前先提供文件供质检审核。以下为指导价；发送询盘获取正式报价、起订量与交期。
¥46 – ¥51.5 /kg
按采购量 · 到上海交货指导价
价格为到上海交货指导区间，采购量越大越接近低端；原料行情每周波动，具体以询盘报价为准，通常 1 个工作日内回复。
供应要点
- 按您的目标规格供货——适用时对标 USP / FCC / JP 药典
- 报价即附近期批次COA，下单前先过您的QA
- 可与其他SKU拼单，上海一票发运
- 发货前可按需安排第三方检测
每批随附文件
批次COA规格书MSDS / SDS出口文件
发货前可按需安排第三方检测；产地证、非转基因或过敏原声明可按目的地市场要求另行安排。
文件先行
每批附COA、规格书与MSDS——发货前即可交由您的QA审核。
现货储备
核心品类多吨位库存，现货SKU上海即刻发运。
认证供应链
货源来自经审核的认证工厂——ISO、HACCP、Halal与Kosher可提供。
灵活出口
25kg袋/箱/桶装；FOB/CIF/DDP按航线，海运空运均可拼货。
02标识与理化性质
标识与理化性质
本品的化合物标识与理化性质。以随报价出具的规格书与批次COA为准。
| CAS 号 | 61-90-5 |
|---|---|
| 分子式 | C6H13NO2 |
| 分子量 | 131.17 |
| EINECS | 200-522-0 |
| 别名 | L-Leucine, L-Leu, L, (2S)-2-amino-4-methylpentanoic acid |
| 外观 | White glistening hexagonal plates or crystalline powder, odourless |
| 溶解性 | Water 24.26 g/L at 25 °C (Merck series: 22.7 g/L at 0 °C, 24.26 at 25 °C, 28.87 at 50 °C, 38.23 at 75 °C, 56.38 at 100 °C; Yalkowsky reports 21.5 g/L at 25 °C). Solubility in 99% alcohol 0.72 g/L; in acetic acid 10.9 g/L; insoluble in ether. Soluble in dilute HCl and in alkaline hydroxides and carbonates. |
| 药典收载情况 | FCC · JP |
03规格参数
规格参数
下表为典型参数——以随报价发送的规格书与批次COA为准。
| 项目 | 规格 | 检测方法 |
|---|---|---|
| Assay (as-is / dried basis) | — | Titration or HPLC per the applicable monograph |
| Appearance | — | Visual |
| Identification | — | IR / specific optical rotation per monograph |
| Specific optical rotation | — | Polarimetry |
| Loss on drying | — | Gravimetric |
| Residue on ignition / sulphated ash | — | Gravimetric |
| Chloride | — | Per monograph |
| Sulphate | — | Per monograph |
| Iron | — | Per monograph |
| Other amino acids / related substances | — | TLC or HPLC per monograph |
| Heavy metals (Pb / As / Cd / Hg) | — | ICP-MS or per monograph |
| Microbiology (TAMC / TYMC / E. coli / Salmonella) | — | USP <61>/<62> or equivalent |
表中显示「—」的项目，表示我们没有可对外公布的固定限度：该项目在批次COA中如实报出，限度与您的质检共同确认。宁可留空，也不编一个数字。 完整的理化、重金属与微生物指标见规格书——随每份报价提供。
04配方与处理要点
配方与处理要点
我们技术团队对采购本品的客户必讲的几件事——决定一批货在您工艺里能不能用起来的关键点。
01
Leucine is the least water-soluble of the three BCAAs — 24.26 g/L at 25 °C against isoleucine's 41.2 and valine's 88.5 — which is why a 2:1:1 BCAA drink is almost always leucine-limited. If a BCAA concentrate throws sediment, leucine is where to look first.
02
It is amphoteric in a useful way for process work: soluble in dilute hydrochloric acid and in alkaline hydroxides and carbonates, but only 0.72 g/L in 99% ethanol. Adjusting pH away from the isoelectric point is the practical lever for getting more leucine into solution, not adding co-solvent.
03
Leucine sublimes and the Merck Index reports decomposition figures ranging from 232 °C to 290 °C, with a melting point cited at 293 °C. It is the most thermally robust of the BCAAs, so it tolerates bar extrusion and hot-fill better than glutamine (which decomposes near 185 °C).
04
Outside nutrition, leucine's hydrophobic surface makes it a recognised glidant and aerosolisation aid in dry-powder formulation — worth knowing because pharmaceutical-grade demand competes for the same supply and moves the price.
05
Leucine and isoleucine are isomers with identical formula (C6H13NO2) and molecular weight (131.17). Specific optical rotation distinguishes them: leucine is reported at -10.8° at 25 °C (c = 2.2 in water) and +15.1° in 6 N HCl. Do not accept a COA that identifies either one by formula alone.
06
Density is reported at 1.293 g/cm3 at 18 °C, but that is the crystal density, not the bulk density that determines whether your scoop volume works. Ask for tapped and bulk density separately if you are scoop-filling.
05应用领域
应用领域
仅面向B2B生产用途——不作任何成品或功效宣称。
BCAA and EAA blends (the dominant single-ingredient use)
Leucine-enriched clinical and sarcopenia nutrition
Protein bars and powders as an amino acid fortifier
Tablet lubricant / glidant in some pharmaceutical formulations
Inhalation powder excipient (leucine is used as an aerosolisation aid)
Capsules and stick packs
06各市场法规状态
各市场法规状态
以资料允许的最保守口径陈述原料的法规状态。这是供应链信息，不构成法规意见——成品与目的地市场的合规判断请咨询您自己的法规顾问。
| 市场 | 状态 | 依据 |
|---|---|---|
| United States | Listed by name in FDA's food-additive regulation for amino acids as 'L-Leucine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 8.8 percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111. | 21 CFR 172.320(a), (b), (c)(4), (e) |
| European Union | Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice. | Directive 2002/46/EC (food supplements); national member-state rules |
| Japan | An Official Monograph titled 'L-Leucine' is listed in the Japanese Pharmacopoeia, Eighteenth Edition. Monograph existence only — no limits transcribed. | JP XVIII, Official Monographs |
| China | Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed. | GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements |
07相关研究文献
相关研究文献
本化合物的同行评议文献，标识号均可点击直达原文——不必只听我们说。
以下文献仅用于提供科学背景。它们描述的是针对该化合物已发表的研究，既不是对本原料的宣称，也不是对任何成品的宣称。致诚生物不作任何医疗、健康或功效宣称。
- A quantitative systematic review reported that ingested leucine dose was associated with the magnitude of the postprandial post-exercise muscle protein synthesis response in older adults but not in younger adults, and that no single plasma leucine variable had substantial predictive capacity. Wilkinson K, Koscien CP, Monteyne AJ, Wall BT, Stephens FB. Physiol Rep. 2023;11(15):e15775. PMID 37537134DOI 10.14814/phy2.15775原文
- A narrative review critically examined the acute and longitudinal literature on isolated leucine and BCAA supplementation for muscular strength and hypertrophy and described the efficacy of BCAAs as an ongoing source of controversy in sports nutrition. Plotkin DL, Delcastillo K, Van Every DW, Tipton KD, Aragon AA, Schoenfeld BJ. Int J Sport Nutr Exerc Metab. 2021;31(3):292-301. PMID 33741748DOI 10.1123/ijsnem.2020-0356原文
- In six healthy young men, muscle protein synthesis after resistance exercise showed a dose response to ingested whole-egg protein and was maximally stimulated at 20 g, with leucine oxidation significantly increased at 20 and 40 g. Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM. Am J Clin Nutr. 2009;89(1):161-168. PMID 19056590DOI 10.3945/ajcn.2008.26401原文
- A biochemical review examined the evidence for and against an anabolic effect of isolated branched-chain amino acid intake on muscle protein synthesis in humans and described the evidence for BCAAs alone as equivocal. Santos CS, Nascimento FEL. Einstein (Sao Paulo). 2019;17(3):eRB4898. PMID 31508659DOI 10.31744/einstein_journal/2019RB4898原文
08包装、储存与交期
包装、储存与交期
| 标准包装 | 25kg袋装、箱装或桶装 |
|---|---|
| 定制包装 | 长期客户可安排定制包装与标签 |
| 储存条件 | 阴凉干燥处，原包装密封保存 |
| 交期 | 按单备货——约1周到上海 |
| 运输 | 上海海运/空运拼货 · FOB/CIF/DDP按航线 |
09采购问答
采购问答
01Why does my BCAA drink go cloudy?
Leucine, nine times out of ten. It is the least soluble BCAA at 24.26 g/L in water at 25 °C, and a leucine-heavy 2:1:1 or 4:1:1 ratio pushes it hardest. Raising temperature or moving pH away from the isoelectric point helps; adding ethanol does not (0.72 g/L in 99% alcohol).
02Can I tell leucine from isoleucine on the COA?
Only by optical rotation or chromatography — the formula and molecular weight are identical. Leucine is reported at about -10.8° at 25 °C (c = 2.2 in water). We will ask the manufacturer to include the rotation on the COA if your QA needs it as an identity test.
03Do you supply pharmaceutical-grade leucine for inhalation or tablet use?
Tell us the monograph and edition you need to comply with and the intended dosage form, and we will go back to the manufacturer. Leucine's use as a glidant and aerosolisation aid has different particle-size and microbiological expectations than a nutritional grade, and it should be specified up front.
04Bulk density — can you give me a number for scoop filling?
The 1.293 g/cm3 in the literature is crystal density and will mislead you. Ask us for the manufacturer's bulk and tapped density on the specification sheet; for scoop-filled products that is the number that decides whether your 5 g scoop actually holds 5 g.
05L-Leucine 的起订量（MOQ）是多少？
MOQ按询盘灵活确定。在询盘中告知目标数量——核心现货SKU通常小试单与多吨位大单都可承接。
06下单前能否获取 L-Leucine 样品？
可以——样品可按需提供，用于评估与实验室验证。在询盘中说明即可，我们逐单确认安排。
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