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L-Isoleucine

速览

L-Isoleucine —— 致诚生物供货速览

致诚生物（Zhicheng Bio）从中国上海供应L-Isoleucine，CAS 73-32-5，非现货，按单排产，每批次随货提供 COA，可另附规格书与 MSDS。询盘请发 zhicheng1@zhicheng-bio.cn，官网不挂价，报价按数量与交货条款单独出。

供应商
致诚生物 Zhicheng Bio，上海
CAS 号
73-32-5
分子式
C6H13NO2
现货状态
按单排产
随货文件
批次 COA；规格书、MSDS 可索取
包装
25 kg 纸箱/袋，可按需调整
PubChem CID
6306
报价方式
邮件询盘（zhicheng1@zhicheng-bio.cn），官网不展示价格
BCAA / EAA undefined

L-Isoleucine

CAS 73-32-5 · C6H13NO2

L-Isoleucine 大宗原料，仅面向 B2B 生产采购——按您的目标规格供货，发货前先提供文件供质检审核。以下为指导价；发送询盘获取正式报价、起订量与交期。

¥40 – ¥44.8 /kg 按采购量 · 到上海交货指导价

价格为到上海交货指导区间，采购量越大越接近低端；原料行情每周波动，具体以询盘报价为准，通常 1 个工作日内回复。

类别: BCAA / EAA
供货状态: undefined
包装: 25 kg 袋装、箱装或桶装（标准）

供应要点

  • 按您的目标规格供货——适用时对标 USP / FCC / JP 药典
  • 报价即附近期批次COA，下单前先过您的QA
  • 可与其他SKU拼单，上海一票发运
  • 发货前可按需安排第三方检测

每批随附文件

批次COA规格书MSDS / SDS出口文件

发货前可按需安排第三方检测；产地证、非转基因或过敏原声明可按目的地市场要求另行安排。

索取COA与报价 使用询盘表单
运费与交期

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索取精确报价

文件先行

每批附COA、规格书与MSDS——发货前即可交由您的QA审核。

现货储备

核心品类多吨位库存，现货SKU上海即刻发运。

认证供应链

货源来自经审核的认证工厂——ISO、HACCP、Halal与Kosher可提供。

灵活出口

25kg袋/箱/桶装；FOB/CIF/DDP按航线，海运空运均可拼货。

02标识与理化性质

标识与理化性质

本品的化合物标识与理化性质。以随报价出具的规格书与批次COA为准。

CAS 号73-32-5
分子式C6H13NO2
分子量131.17
EINECS200-798-2
别名L-Isoleucine, L-Ile, I, (2S,3S)-2-amino-3-methylpentanoic acid
外观White to off-white crystalline powder; waxy, shiny rhombic leaflets when crystallised from alcohol
溶解性Water 41.2 g/L at 25 °C (Merck series: 37.9 g/L at 0 °C, 41.2 at 25 °C, 48.2 at 50 °C, 60.8 at 75 °C, 82.6 at 100 °C; Yalkowsky reports 34.4 g/L at 25 °C). Sparingly soluble in hot alcohol (0.13% w/w at 80 °C) and hot acetic acid; insoluble in ether.
药典收载情况FCC · JP
03规格参数

规格参数

下表为典型参数——以随报价发送的规格书与批次COA为准。

项目规格检测方法
Assay (as-is / dried basis)—Titration or HPLC per the applicable monograph
Appearance—Visual
Identification—IR / specific optical rotation per monograph
Specific optical rotation—Polarimetry
Loss on drying—Gravimetric
Residue on ignition / sulphated ash—Gravimetric
Chloride—Per monograph
Sulphate—Per monograph
Iron—Per monograph
Other amino acids / related substances—TLC or HPLC per monograph
Heavy metals (Pb / As / Cd / Hg)—ICP-MS or per monograph
Microbiology (TAMC / TYMC / E. coli / Salmonella)—USP <61>/<62> or equivalent

表中显示「—」的项目，表示我们没有可对外公布的固定限度：该项目在批次COA中如实报出，限度与您的质检共同确认。宁可留空，也不编一个数字。 完整的理化、重金属与微生物指标见规格书——随每份报价提供。

04配方与处理要点

配方与处理要点

我们技术团队对采购本品的客户必讲的几件事——决定一批货在您工艺里能不能用起来的关键点。

01

Isoleucine is the middle child of the BCAA trio on solubility and it decides the character of a BCAA beverage. In water at 25 °C: isoleucine 41.2 g/L, valine 88.5 g/L, leucine 24.3 g/L (Merck values). In a 2:1:1 leucine-heavy blend, leucine hits its ceiling first, but isoleucine is what limits you next.

02

It is distinctly bitter — the Merck Index lists the taste as bitter — and unlike leucine it does not bring a compensating mouthfeel. Bitterness masking in an unflavoured BCAA is largely an isoleucine and leucine problem.

03

Its solubility climbs steeply with temperature (37.9 g/L at 0 °C to 82.6 g/L at 100 °C), so a hot-fill or warm-mix step buys you real headroom — but the same curve means a cold-chain product can precipitate.

04

Practically insoluble in organic solvents (0.13% w/w in hot alcohol at 80 °C, insoluble in ether), so it is an aqueous and dry-blend ingredient only.

05

Isoleucine and leucine share the molecular formula C6H13NO2 and the molecular weight 131.17 — they are structural isomers. That means formula and MW alone cannot distinguish them on a document; the identity test that matters is specific optical rotation (isoleucine is reported at +40.6° at 20 °C, c = 4.6 in 6.1 N HCl) or a chromatographic method. Insist on one of those on the COA.

05应用领域

应用领域

仅面向B2B生产用途——不作任何成品或功效宣称。

BCAA 2:1:1 and 4:1:1 blends
EAA and free-form amino acid powders
Intra-workout beverages
Clinical and enteral nutrition
Capsules and tablets
06各市场法规状态

各市场法规状态

以资料允许的最保守口径陈述原料的法规状态。这是供应链信息，不构成法规意见——成品与目的地市场的合规判断请咨询您自己的法规顾问。

市场状态依据
United StatesListed by name in FDA's food-additive regulation for amino acids as 'L-Isoleucine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 6.6 percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111.21 CFR 172.320(a), (b), (c)(4), (e)
European UnionAmino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice.Directive 2002/46/EC (food supplements); national member-state rules
JapanAn Official Monograph titled 'L-Isoleucine' is listed in the Japanese Pharmacopoeia, Eighteenth Edition. Monograph existence only — no limits transcribed.JP XVIII, Official Monographs
ChinaStatus as a nutrient fortification substance / food additive under Chinese national standards to be confirmed.GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements
07相关研究文献

相关研究文献

本化合物的同行评议文献，标识号均可点击直达原文——不必只听我们说。

以下文献仅用于提供科学背景。它们描述的是针对该化合物已发表的研究，既不是对本原料的宣称，也不是对任何成品的宣称。致诚生物不作任何医疗、健康或功效宣称。

  1. In rats, a single oral dose of isoleucine (0.3 g/kg) significantly reduced plasma glucose at 30 and 60 minutes after a glucose bolus whereas leucine and valine did not, and 1 mM isoleucine increased glucose consumption in C2C12 myotubes by 16.8% in the absence of insulin. Doi M, Yamaoka I, Fukunaga T, Nakayama M. Biochem Biophys Res Commun. 2003;312(4):1111-1117. PMID 14651987DOI 10.1016/j.bbrc.2003.11.039原文
  2. In fasted rats, oral isoleucine decreased plasma glucose by 20% and increased muscle glucose uptake by 71% without a significant rise in plasma insulin, and inhibited glucose production from alanine in isolated hepatocytes. Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Am J Physiol Endocrinol Metab. 2007;292(6):E1683-E1693. PMID 17299083DOI 10.1152/ajpendo.00609.2006原文
  3. A systematic review of oral branched-chain amino acid supplementation in athletes assessed the available trials and reported that the evidence base among athletic populations is not clear-cut. Martinho DV, Nobari H, Faria A, Field A, Duarte D, Sarmento H. Nutrients. 2022;14(19):4002. PMID 36235655DOI 10.3390/nu14194002原文
08包装、储存与交期

包装、储存与交期

标准包装25kg袋装、箱装或桶装
定制包装长期客户可安排定制包装与标签
储存条件阴凉干燥处，原包装密封保存
交期undefined
运输上海海运/空运拼货 · FOB/CIF/DDP按航线
09采购问答

采购问答

01How do I prove a lot is isoleucine and not leucine?
Not from the formula or molecular weight — they are identical (C6H13NO2, 131.17). Ask for specific optical rotation or a chromatographic identity on the COA. Isoleucine is reported at about +40.6° at 20 °C, c = 4.6 in 6.1 N HCl. This is a real risk on cheap BCAA offers and worth checking on first shipment.
02What is the practical solubility limit for a BCAA drink?
Isoleucine is 41.2 g/L in water at 25 °C. In a 2:1:1 blend leucine (24.3 g/L) caps you first and isoleucine second. Warm mixing helps materially — isoleucine roughly doubles to 82.6 g/L at 100 °C — but you have to design for the coldest temperature the finished product will see.
03Is your isoleucine fermentation-derived or hair-hydrolysate?
Ask and we will get it in writing. Origin matters for vegan, kosher and halal claims and for some destination markets. We source from audited manufacturers and can supply an origin/non-animal declaration where the manufacturer issues one.
04Stock and lead time on this SKU?
This is a small ready-stock item (about 75 kg on hand). Larger quantities are procured to order, typically about one week to Shanghai — worth consolidating with leucine and valine into one shipment.
05L-Isoleucine 的起订量（MOQ）是多少？
MOQ按询盘灵活确定。在询盘中告知目标数量——核心现货SKU通常小试单与多吨位大单都可承接。
06下单前能否获取 L-Isoleucine 样品？
可以——样品可按需提供，用于评估与实验室验证。在询盘中说明即可，我们逐单确认安排。
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