ZHICHENG BIO
氨基酸undefined
L-Arginine Base
USP32
¥22 – ¥24.6 /kg按采购量
01产品详情
L-Histidine HCl Monohydrate 83% L-Histidine
速览
L-Histidine HCl Monohydrate —— 致诚生物供货速览
致诚生物（Zhicheng Bio）从中国上海供应L-Histidine HCl Monohydrate（83% L-Histidine），CAS 5934-29-2，非现货，按单排产，每批次随货提供 COA，可另附规格书与 MSDS。按单备货——约1周到上海。询盘请发 zhicheng1@zhicheng-bio.cn，官网不挂价，报价按数量与交货条款单独出。
- 供应商
- 致诚生物 Zhicheng Bio，上海
- CAS 号
- 5934-29-2
- 分子式
- C6H9N3O2·HCl·H2O
- 规格
- 83% L-Histidine
- 现货状态
- 按单排产
- 随货文件
- 批次 COA；规格书、MSDS 可索取
- 包装
- 25 kg 纸箱/袋，可按需调整
- PubChem CID
- 165377
- 报价方式
- 邮件询盘（zhicheng1@zhicheng-bio.cn），官网不展示价格
氨基酸
约1周
L-Histidine HCl Monohydrate
83% L-Histidine
CAS 5934-29-2 · C6H9N3O2·HCl·H2O
L-Histidine HCl Monohydrate 大宗原料，仅面向 B2B 生产采购——按您的目标规格供货，发货前先提供文件供质检审核。以下为指导价；发送询盘获取正式报价、起订量与交期。
¥76 – ¥85.1 /kg
按采购量 · 到上海交货指导价
价格为到上海交货指导区间，采购量越大越接近低端；原料行情每周波动，具体以询盘报价为准，通常 1 个工作日内回复。
供应要点
- 按您的目标规格供货——适用时对标 USP / FCC / JP 药典
- 报价即附近期批次COA，下单前先过您的QA
- 可与其他SKU拼单，上海一票发运
- 发货前可按需安排第三方检测
每批随附文件
批次COA规格书MSDS / SDS出口文件
发货前可按需安排第三方检测；产地证、非转基因或过敏原声明可按目的地市场要求另行安排。
文件先行
每批附COA、规格书与MSDS——发货前即可交由您的QA审核。
现货储备
核心品类多吨位库存，现货SKU上海即刻发运。
认证供应链
货源来自经审核的认证工厂——ISO、HACCP、Halal与Kosher可提供。
灵活出口
25kg袋/箱/桶装；FOB/CIF/DDP按航线，海运空运均可拼货。
02标识与理化性质
标识与理化性质
本品的化合物标识与理化性质。以随报价出具的规格书与批次COA为准。
| CAS 号 | 5934-29-2 |
|---|---|
| 分子式 | C6H12ClN3O3 (written as C6H9N3O2·HCl·H2O) |
| 分子量 | 209.63 |
| EINECS | 611-821-4 |
| 别名 | Histidine monohydrochloride monohydrate, L-Histidine HCl H2O, L-His-HCl monohydrate |
| 外观 | White crystalline powder |
| 溶解性 | Fairly soluble in water; insoluble in alcohol and ether (Merck Index, for the monohydrochloride). Free-base L-histidine for comparison: 45.6 g/L in water at 25 °C. |
| 药典收载情况 | JP (as L-Histidine Hydrochloride Hydrate) |
03规格参数
规格参数
下表为典型参数——以随报价发送的规格书与批次COA为准。
| 项目 | 规格 | 检测方法 |
|---|---|---|
| Stated L-histidine content | 83% (as printed on the offer sheet) — see verify note | Per supplier offer sheet |
| Water (as monohydrate) | — | Karl Fischer or loss on drying |
| Assay (as-is / dried basis) | — | Titration or HPLC per the applicable monograph |
| Appearance | — | Visual |
| Identification | — | IR / specific optical rotation per monograph |
| Specific optical rotation | — | Polarimetry |
| Loss on drying | — | Gravimetric |
| Residue on ignition / sulphated ash | — | Gravimetric |
| Chloride | — | Per monograph |
| Sulphate | — | Per monograph |
| Iron | — | Per monograph |
| Other amino acids / related substances | — | TLC or HPLC per monograph |
| Heavy metals (Pb / As / Cd / Hg) | — | ICP-MS or per monograph |
| Microbiology (TAMC / TYMC / E. coli / Salmonella) | — | USP <61>/<62> or equivalent |
表中显示「—」的项目，表示我们没有可对外公布的固定限度：该项目在批次COA中如实报出，限度与您的质检共同确认。宁可留空，也不编一个数字。 完整的理化、重金属与微生物指标见规格书——随每份报价提供。
04配方与处理要点
配方与处理要点
我们技术团队对采购本品的客户必讲的几件事——决定一批货在您工艺里能不能用起来的关键点。
01
Histidine is the only proteinogenic amino acid with a side-chain pKa in the physiological range — the imidazole group sits near pK 5.97 (Merck reports pK1' 1.78, pK2' 5.97, pK3' 8.97 for the free base). That is precisely why histidine is used as a buffer in biologics formulation, and it is also why a histidine addition will buffer your own product around pH 6 whether you wanted it to or not.
02
This is a monohydrate salt, so three different weights exist for the same material: the hydrated salt (209.63), the anhydrous salt (191.62) and the free base (155.15). Free histidine is 74.0% of the hydrated salt. Every potency calculation must state which basis it is on.
03
The hydrochloride form is chosen over the free base for solubility and handling — Merck describes the monohydrochloride as fairly soluble in water and insoluble in alcohol and ether, and the free base is only 45.6 g/L in water at 25 °C.
04
Water of crystallisation makes loss-on-drying a specification parameter rather than a purity check. A 'dry' lot that has lost its hydrate water will over-assay on the salt basis and under-deliver on a histidine-content basis.
05
In a beta-alanine stack, histidine is the co-substrate of the carnosine synthesis pathway, so the pairing is common commercially — but the two ingredients have very different solubility and taste profiles and should be evaluated separately in the flavour system.
05应用领域
应用领域
仅面向B2B生产用途——不作任何成品或功效宣称。
Free-form amino acid and EAA blends
Carnosine and beta-alanine stack formulations
Clinical, enteral and parenteral nutrition raw material
Buffer preparation and biopharmaceutical formulation (histidine is a common protein-formulation buffer)
Cell-culture media
06各市场法规状态
各市场法规状态
以资料允许的最保守口径陈述原料的法规状态。这是供应链信息，不构成法规意见——成品与目的地市场的合规判断请咨询您自己的法规顾问。
| 市场 | 状态 | 依据 |
|---|---|---|
| United States | Listed by name in FDA's food-additive regulation for amino acids as 'L-Histidine'. That regulation permits use as a nutrient 'to significantly improve the biological quality of the total protein' of a food, subject to a cap of 2.4 percent by weight of the total protein of the finished food, and to the labelling requirements in paragraph (e). It is not a general-purpose clearance for any food use, and it is not the authority under which dietary supplements are marketed — those sit under DSHEA and 21 CFR part 111. | 21 CFR 172.320(a), (b), (c)(4), (e) |
| European Union | Amino acids are not covered by the harmonised positive lists of Directive 2002/46/EC (Annexes I and II of that Directive cover vitamins and minerals only). Amino acid ingredients are therefore governed by general EU food law plus national rules, with mutual recognition under Article 4 of Regulation (EC) No 764/2008 in practice. | Directive 2002/46/EC (food supplements); national member-state rules |
| Japan | An Official Monograph titled 'L-Histidine Hydrochloride Hydrate' is listed in the Japanese Pharmacopoeia, Eighteenth Edition. Monograph existence only — no limits transcribed. | JP XVIII, Official Monographs |
| China | Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed. | GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements |
07相关研究文献
相关研究文献
本化合物的同行评议文献，标识号均可点击直达原文——不必只听我们说。
以下文献仅用于提供科学背景。它们描述的是针对该化合物已发表的研究，既不是对本原料的宣称，也不是对任何成品的宣称。致诚生物不作任何医疗、健康或功效宣称。
- A review of histidine intake reported that supplementation at 4.0-4.5 g/day and increased dietary histidine intake have been associated with lower BMI, adiposity, markers of glucose homeostasis, pro-inflammatory cytokines and oxidative stress, and noted that studies report adverse effects at high intakes above roughly 24 g/day. Thalacker-Mercer AE, Gheller ME. J Nutr. 2020;150(Suppl 1):2588S-2592S. PMID 33000165DOI 10.1093/jn/nxaa229原文
- A physiological review of carnosine identified L-histidine, and specifically its imidazole moiety, as the prime bioactive component of the dipeptide, with beta-alanine mainly regulating the rate of carnosine synthesis. Boldyrev AA, Aldini G, Derave W. Physiol Rev. 2013;93(4):1803-1845. PMID 24137022DOI 10.1152/physrev.00039.2012原文
- A review of the side effects of amino acid supplements examined histidine among other amino acids and discussed competition for shared membrane carriers and degradative enzymes at high intakes. Holeček M. Physiol Res. 2022;71(1):29-45. PMID 35043647DOI 10.33549/physiolres.934790原文
08包装、储存与交期
包装、储存与交期
| 标准包装 | 25kg袋装、箱装或桶装 |
|---|---|
| 定制包装 | 长期客户可安排定制包装与标签 |
| 储存条件 | 阴凉干燥处，原包装密封保存 |
| 交期 | 按单备货——约1周到上海 |
| 运输 | 上海海运/空运拼货 · FOB/CIF/DDP按航线 |
09采购问答
采购问答
01The listing says 83% L-histidine. Is that right?
That figure needs checking and we would rather flag it than let you build a label on it. For L-histidine hydrochloride monohydrate, free histidine cannot exceed 74.0% of the salt mass (155.15/209.63) — even the anhydrous salt is only 81.0%. The 83% almost certainly refers to an assay of the salt, not to histidine content. Ask us for the manufacturer's specification sheet and we will get the basis stated unambiguously before you order.
02Do I need the hydrochloride or the free base?
Take the hydrochloride when you need solubility and easy handling; take the free base when you want maximum histidine per kilogram and can accept lower water solubility (45.6 g/L at 25 °C). For buffer work the choice is usually driven by the pH you are targeting and whether you can tolerate chloride.
03Why does histidine change my product's pH more than other amino acids?
Because it is the one amino acid whose side chain buffers in the range you care about — the imidazole pK is around 6. That is the whole reason histidine is used as a formulation buffer for biologics. Expect it to pull your system toward pH 6 and plan your buffer accordingly.
04How should the water content be specified?
As a range, not as a maximum. It is a monohydrate: theoretical water is 8.6%. A lot that has dried out will read high on a salt-basis assay and low on histidine content. Ask for Karl Fischer water on the COA.
05L-Histidine HCl Monohydrate 的起订量（MOQ）是多少？
MOQ按询盘灵活确定。在询盘中告知目标数量——核心现货SKU通常小试单与多吨位大单都可承接。
06下单前能否获取 L-Histidine HCl Monohydrate 样品？
可以——样品可按需提供，用于评估与实验室验证。在询盘中说明即可，我们逐单确认安排。
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