ZHICHENG BIO
肌酸系列约1周
Creatine Hydrochloride
78% Creatine
¥37 – ¥41.4 /kg按采购量
01产品详情
Creatine Monohydrate 颗粒
速览
Creatine Monohydrate —— 致诚生物供货速览
致诚生物（Zhicheng Bio）从中国上海供应Creatine Monohydrate（颗粒），CAS 6020-87-7，非现货，按单排产，每批次随货提供 COA，可另附规格书与 MSDS。交期较长——约2周到上海。询盘请发 zhicheng1@zhicheng-bio.cn，官网不挂价，报价按数量与交货条款单独出。
- 供应商
- 致诚生物 Zhicheng Bio，上海
- CAS 号
- 6020-87-7
- 分子式
- C4H9N3O2·H2O
- 规格
- 颗粒
- 现货状态
- 按单排产
- 随货文件
- 批次 COA；规格书、MSDS 可索取
- 包装
- 25 kg 纸箱/袋，可按需调整
- PubChem CID
- 80116
- 报价方式
- 邮件询盘（zhicheng1@zhicheng-bio.cn），官网不展示价格
肌酸系列
约2周
Creatine Monohydrate
颗粒
CAS 6020-87-7 · C4H9N3O2·H2O
Creatine Monohydrate 大宗原料，仅面向 B2B 生产采购——按您的目标规格供货，发货前先提供文件供质检审核。以下为指导价；发送询盘获取正式报价、起订量与交期。
¥33 – ¥37 /kg
按采购量 · 到上海交货指导价
价格为到上海交货指导区间，采购量越大越接近低端；原料行情每周波动，具体以询盘报价为准，通常 1 个工作日内回复。
供应要点
- 按您的目标规格供货——适用时对标 USP / FCC / JP 药典
- 报价即附近期批次COA，下单前先过您的QA
- 可与其他SKU拼单，上海一票发运
- 发货前可按需安排第三方检测
每批随附文件
批次COA规格书MSDS / SDS出口文件
发货前可按需安排第三方检测；产地证、非转基因或过敏原声明可按目的地市场要求另行安排。
文件先行
每批附COA、规格书与MSDS——发货前即可交由您的QA审核。
现货储备
核心品类多吨位库存，现货SKU上海即刻发运。
认证供应链
货源来自经审核的认证工厂——ISO、HACCP、Halal与Kosher可提供。
灵活出口
25kg袋/箱/桶装；FOB/CIF/DDP按航线，海运空运均可拼货。
02标识与理化性质
标识与理化性质
本品的化合物标识与理化性质。以随报价出具的规格书与批次COA为准。
| CAS 号 | 6020-87-7 |
|---|---|
| 分子式 | C4H11N3O3 (written as C4H9N3O2·H2O) |
| 分子量 | 149.15 |
| EINECS | 611-954-8 |
| 别名 | Creatine monohydrate, CrM, N-methyl-N-guanylglycine monohydrate, methylguanidinoacetic acid monohydrate |
| 外观 | White crystalline granular powder, odourless |
| 溶解性 | Sparingly soluble in water. Creatine base is 13.3 g/L at 18 °C; the Merck Index states that 1 g of the monohydrate dissolves in 75 mL of water (about 13 g/L); a 2026 peer-reviewed review states that the thermodynamic solubility of creatine monohydrate in water at 25 °C does not exceed 13 g/L. Slightly soluble in ethanol and ether. |
03规格参数
规格参数
下表为典型参数——以随报价发送的规格书与批次COA为准。
| 项目 | 规格 | 检测方法 |
|---|---|---|
| Creatine content (anhydrous basis) | 87.9% theoretical | Calculated from molecular weights |
| Water (as monohydrate) | 12.1% theoretical | Karl Fischer or loss on drying |
| Creatinine | — | HPLC |
| Dicyandiamide | — | HPLC |
| Dihydrotriazine | — | HPLC |
| Particle size / mesh | Granular (not micronised) — confirm the distribution | Sieve analysis |
| Assay (as-is / dried basis) | — | Titration or HPLC per the applicable monograph |
| Appearance | — | Visual |
| Identification | — | IR / specific optical rotation per monograph |
| Specific optical rotation | — | Polarimetry |
| Loss on drying | — | Gravimetric |
| Residue on ignition / sulphated ash | — | Gravimetric |
| Chloride | — | Per monograph |
| Sulphate | — | Per monograph |
| Iron | — | Per monograph |
| Other amino acids / related substances | — | TLC or HPLC per monograph |
| Heavy metals (Pb / As / Cd / Hg) | — | ICP-MS or per monograph |
| Microbiology (TAMC / TYMC / E. coli / Salmonella) | — | USP <61>/<62> or equivalent |
表中显示「—」的项目，表示我们没有可对外公布的固定限度：该项目在批次COA中如实报出，限度与您的质检共同确认。宁可留空，也不编一个数字。 完整的理化、重金属与微生物指标见规格书——随每份报价提供。
04配方与处理要点
配方与处理要点
我们技术团队对采购本品的客户必讲的几件事——决定一批货在您工艺里能不能用起来的关键点。
01
This is the granular grade, and the reason that matters is flow, not chemistry. Granular creatine flows and fills consistently through a tablet press, a capsule filler and a volumetric doser; micronised 200-mesh creatine dissolves faster but bridges, dusts and segregates. If you are tabletting or capsuling, granular is the right grade. If you are selling on 'dissolves instantly', it is not.
02
Creatine is genuinely sparingly soluble and formulators consistently underestimate it. A 2026 peer-reviewed review states that thermodynamic solubility in water at 25 °C does not exceed 13 g/L, and the Merck Index puts it at 1 g in 75 mL. A 5 g serving therefore needs roughly 400 mL of water to fully dissolve at room temperature. Anything less is a suspension, which is fine but should be described honestly on the label.
03
Micronisation is the industry answer to that, and it is a real effect rather than a marketing one: published work reports mean particle size reduced from 44.67 µm to 0.36-9.06 µm with the needle-like crystals becoming spherical, giving faster dissolution and higher apparent solubility. It also gives you a dustier, worse-flowing powder — hence two grades.
04
Creatinine is the number that defines creatine quality. Creatine cyclises to creatinine, the reaction is acid-catalysed and heat-accelerated, and creatinine is what a competitor's lab will look for if they test your product. Insist on a creatinine limit on every lot.
05
Dicyandiamide and dihydrotriazine are the synthesis-related impurities European buyers name explicitly in their creatine specifications. Have the limits in hand before an EU customer asks.
06
It is a monohydrate, so 12.1% of the mass is water of crystallisation and only 87.9% is creatine. A 5 g creatine claim needs 5.69 g of monohydrate. This is also why an over-dried lot will over-assay on a creatine basis while being out of specification on water.
07
Published stress work found structural modification of creatine under thermal stress from 60 °C upward, UV exposure, pH extremes and in common beverage matrices including coffee, orange juice and energy drink. Any wet or hot creatine application needs its own stability study, not an assumption.
08
Lead time on this SKU is about two weeks rather than the one week typical of the range, because the granular grade is made to order in campaign quantities. Plan a creatine launch around that.
05应用领域
应用领域
仅面向B2B生产用途——不作任何成品或功效宣称。
Creatine powders and tubs (the granular grade's core market)
Capsules and tablets, where granular flow beats micronised powder
Protein powders and meal-replacement blends
Bars and dry powdered drink mixes
Gummies and chews
06各市场法规状态
各市场法规状态
以资料允许的最保守口径陈述原料的法规状态。这是供应链信息，不构成法规意见——成品与目的地市场的合规判断请咨询您自己的法规顾问。
| 市场 | 状态 | 依据 |
|---|---|---|
| United States | GRAS Notice GRN 931 (notifier AlzChem Trostberg GmbH) for creatine monohydrate closed with an 'FDA has no questions' letter in 2020. The notified use was as 'an ingredient in energy drinks, protein bars and powders, milk shakes, meal replacement bars and powders, meat analogs, and dry powdered drink mixes' at 1.2 g per serving, equivalent to 1.0 g creatine per serving. A GRAS notice is specific to the notifier's substance and use; it is not transferable to another manufacturer's material without an equivalence assessment. Creatine is not listed in 21 CFR 172.320. | FDA GRAS Notice Inventory GRN 931; 21 CFR 172.320 |
| European Union | Creatine monohydrate has a long-established position in EU food supplements. EU buyers conventionally require limits on dicyandiamide and dihydrotriazine on the creatine specification. | EU food supplement law; industry specification practice |
| China | Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed. Creatine's status in China as a food ingredient versus a health-food (保健食品) ingredient should be checked separately — this is a real distinction for domestic Chinese customers. | GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements |
| Japan | No JP XVIII Official Monograph for this substance was located. | JP XVIII |
07相关研究文献
相关研究文献
本化合物的同行评议文献，标识号均可点击直达原文——不必只听我们说。
以下文献仅用于提供科学背景。它们描述的是针对该化合物已发表的研究，既不是对本原料的宣称，也不是对任何成品的宣称。致诚生物不作任何医疗、健康或功效宣称。
- A review reported that the thermodynamic solubility of creatine monohydrate in water at 25 °C does not exceed 13 g/L, and surveyed micronisation and granulation approaches, including a study in which mean particle size fell from 44.67 µm to 0.36-9.06 µm with the crystals changing from needle-like to spherical, and granulation producing free-flowing dust-free granules. Pharmaceuticals (Basel). 2026;19(1):128. PMID 41599726DOI 10.3390/ph19010128原文
- A multi-analytical study characterised creatine degradation under thermal stress (60-200 °C), UV light, pH variation (pH 3, 8 and 13) and common beverage matrices (coffee, orange juice and energy drink), using ATR-FTIR and high-resolution mass spectrometry to identify the structural modifications relevant to storage, transport and preparation of creatine supplements. Saiki PY, Sales GM, de Oliveira AN, Catharino RR. Food Res Int. 2025;221(Pt 3):117472. PMID 41214971DOI 10.1016/j.foodres.2025.117472原文
- A position stand of the International Society of Sports Nutrition reported that studies have consistently shown creatine supplementation increases intramuscular creatine concentrations, and reviewed the safety and efficacy literature on creatine in exercise, sport and medicine. Kreider RB, Kalman DS, Antonio J, et al. J Int Soc Sports Nutr. 2017;14:18. PMID 28615996DOI 10.1186/s12970-017-0173-z原文
- A systematic review and meta-analysis of randomised placebo-controlled trials in postmenopausal women examined creatine monohydrate supplementation, with or without resistance training, against DXA-derived lean mass, one-repetition-maximum strength, bone mineral density, physical function and safety outcomes. Naddafha S, Antonio J, Kreider RB, Stout JR. J Int Soc Sports Nutr. 2026;23(1):2668435. PMID 42141930DOI 10.1080/15502783.2026.2668435原文
- In a randomised trial, eight weeks of resistance training with creatine monohydrate (with and without a five-day loading phase), creatine hydrochloride, or placebo produced significant increases in strength, muscular cross-sectional area and skeletal muscle mass in the supplemented groups relative to placebo. Eghbali E, Arazi H, Suzuki K. Physiol Res. 2024;73(5):739-753. PMID 39545789DOI 10.33549/physiolres.935323原文
08包装、储存与交期
包装、储存与交期
| 标准包装 | 25kg袋装、箱装或桶装 |
|---|---|
| 定制包装 | 长期客户可安排定制包装与标签 |
| 储存条件 | 阴凉干燥处，原包装密封保存 |
| 交期 | 交期较长——约2周到上海 |
| 运输 | 上海海运/空运拼货 · FOB/CIF/DDP按航线 |
09采购问答
采购问答
01Granular or micronised — which should I buy?
Granular if you are tabletting, capsuling or volumetrically dosing, because it flows and fills without bridging or dusting. Micronised if your product's promise is instant dissolution in a shaker. Published work shows micronisation genuinely does cut particle size from about 45 µm to under 10 µm and speeds dissolution — it also gives you a dustier, worse-flowing powder. We can quote either; tell us your dosage form.
02How much water does 5 g of creatine actually need?
About 400 mL at room temperature. Creatine monohydrate's solubility does not exceed 13 g/L at 25 °C — the Merck Index puts it at 1 g in 75 mL. Anything more concentrated than that is a suspension. That is perfectly workable, but say so on the label rather than promising a clear solution.
03Which impurity limits must be on the COA?
Creatinine, dicyandiamide and dihydrotriazine. Creatinine is the degradation marker every lab checks; dicyandiamide and dihydrotriazine are the synthesis-related impurities European buyers name in their specifications. We will request all three limits with your quotation.
04Does FDA's creatine GRAS notice cover my product?
Read it carefully before assuming so. GRN 931 closed with an 'FDA has no questions' letter for creatine monohydrate in specific categories at 1.2 g per serving, equal to 1.0 g creatine. A GRAS notice belongs to the notifier's substance and use. If your customer needs equivalence to it, tell us and we will put the question to the manufacturer in writing.
05Can I put creatine in a bottled drink or a hot-filled product?
Only with your own stability data. Published stress testing found structural changes to creatine under thermal stress from 60 °C, under UV, at pH extremes, and in beverage matrices including coffee, orange juice and energy drink. Creatine converts to creatinine faster when hot and acidic. Run a real accelerated study at your pH and fill temperature.
06What is the lead time and how much can you hold?
Roughly 7-10 tonnes available with about two weeks to Shanghai — longer than most of our range, because the granular grade is made in campaigns rather than held loose. Build that into a launch schedule and we will discuss holding stock against a forecast.
07Creatine Monohydrate 的起订量（MOQ）是多少？
MOQ按询盘灵活确定。在询盘中告知目标数量——核心现货SKU通常小试单与多吨位大单都可承接。
08下单前能否获取 Creatine Monohydrate 样品？
可以——样品可按需提供，用于评估与实验室验证。在询盘中说明即可，我们逐单确认安排。
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