ZHICHENG BIO
肌酸系列约2周
Creatine Monohydrate
颗粒
¥33 – ¥37 /kg按采购量
01产品详情
Creatine Hydrochloride 78% Creatine
速览
Creatine Hydrochloride —— 致诚生物供货速览
致诚生物（Zhicheng Bio）从中国上海供应Creatine Hydrochloride（78% Creatine），CAS 17050-09-8，非现货，按单排产，每批次随货提供 COA，可另附规格书与 MSDS。按单备货——约1周到上海。询盘请发 zhicheng1@zhicheng-bio.cn，官网不挂价，报价按数量与交货条款单独出。
- 供应商
- 致诚生物 Zhicheng Bio，上海
- CAS 号
- 17050-09-8
- 分子式
- C4H9N3O2·HCl
- 规格
- 78% Creatine
- 现货状态
- 按单排产
- 随货文件
- 批次 COA；规格书、MSDS 可索取
- 包装
- 25 kg 纸箱/袋，可按需调整
- PubChem CID
- 134732
- 报价方式
- 邮件询盘（zhicheng1@zhicheng-bio.cn），官网不展示价格
肌酸系列
约1周
Creatine Hydrochloride
78% Creatine
CAS 17050-09-8 · C4H9N3O2·HCl
Creatine Hydrochloride 大宗原料，仅面向 B2B 生产采购——按您的目标规格供货，发货前先提供文件供质检审核。以下为指导价；发送询盘获取正式报价、起订量与交期。
¥37 – ¥41.4 /kg
按采购量 · 到上海交货指导价
价格为到上海交货指导区间，采购量越大越接近低端；原料行情每周波动，具体以询盘报价为准，通常 1 个工作日内回复。
供应要点
- 按您的目标规格供货——适用时对标 USP / FCC / JP 药典
- 报价即附近期批次COA，下单前先过您的QA
- 可与其他SKU拼单，上海一票发运
- 发货前可按需安排第三方检测
每批随附文件
批次COA规格书MSDS / SDS出口文件
发货前可按需安排第三方检测；产地证、非转基因或过敏原声明可按目的地市场要求另行安排。
文件先行
每批附COA、规格书与MSDS——发货前即可交由您的QA审核。
现货储备
核心品类多吨位库存，现货SKU上海即刻发运。
认证供应链
货源来自经审核的认证工厂——ISO、HACCP、Halal与Kosher可提供。
灵活出口
25kg袋/箱/桶装；FOB/CIF/DDP按航线，海运空运均可拼货。
02标识与理化性质
标识与理化性质
本品的化合物标识与理化性质。以随报价出具的规格书与批次COA为准。
| CAS 号 | 17050-09-8 |
|---|---|
| 分子式 | C4H10ClN3O2 (written as C4H9N3O2·HCl) |
| 分子量 | 167.59 |
| EINECS | 811-182-3 |
| 别名 | Creatine HCl, Cr-HCl, creatine monohydrochloride, 2-[carbamimidoyl(methyl)amino]acetic acid hydrochloride |
| 外观 | White crystalline powder |
| 溶解性 | Substantially more soluble in water than creatine monohydrate |
03规格参数
规格参数
下表为典型参数——以随报价发送的规格书与批次COA为准。
| 项目 | 规格 | 检测方法 |
|---|---|---|
| Creatine content (free base equivalent) | 78.2% theoretical (offer sheet states 78%) | Calculated from molecular weights |
| Creatinine | — | HPLC |
| Dicyandiamide and dihydrotriazine | — | HPLC |
| pH (aqueous solution) | — | Potentiometric |
| Assay (as-is / dried basis) | — | Titration or HPLC per the applicable monograph |
| Appearance | — | Visual |
| Identification | — | IR / specific optical rotation per monograph |
| Specific optical rotation | — | Polarimetry |
| Loss on drying | — | Gravimetric |
| Residue on ignition / sulphated ash | — | Gravimetric |
| Chloride | — | Per monograph |
| Sulphate | — | Per monograph |
| Iron | — | Per monograph |
| Other amino acids / related substances | — | TLC or HPLC per monograph |
| Heavy metals (Pb / As / Cd / Hg) | — | ICP-MS or per monograph |
| Microbiology (TAMC / TYMC / E. coli / Salmonella) | — | USP <61>/<62> or equivalent |
表中显示「—」的项目，表示我们没有可对外公布的固定限度：该项目在批次COA中如实报出，限度与您的质检共同确认。宁可留空，也不编一个数字。 完整的理化、重金属与微生物指标见规格书——随每份报价提供。
04配方与处理要点
配方与处理要点
我们技术团队对采购本品的客户必讲的几件事——决定一批货在您工艺里能不能用起来的关键点。
01
Creatine hydrochloride exists for one reason: dissolution. Creatine itself is only sparingly soluble — the base is 13.3 g/L in water at 18 °C, and a peer-reviewed review puts creatine monohydrate's thermodynamic solubility at no more than 13 g/L at 25 °C. The hydrochloride is substantially more soluble, which is what makes a small-volume or clear-liquid creatine format possible at all.
02
Higher solubility is not the same as higher stability, and this is where creatine HCl is routinely over-sold. Creatine cyclises to creatinine in solution, and that reaction is acid-catalysed — so a salt whose whole selling point is an acidic, freely soluble solution is being pushed toward its own degradation pathway. Solubility solves the mixing problem and can worsen the shelf-life problem.
03
Which makes creatinine the row to fight over on the COA. Every creatine specification should carry a creatinine limit; a creatine HCl specification without one tells you nothing about how the lot was made or stored.
04
Potency is 78.2% creatine (131.13/167.59) against 87.9% for the monohydrate. Per gram of creatine delivered, the hydrochloride is the more expensive route on this offer sheet even before the price difference — a 5 g creatine dose needs 6.39 g of HCl salt versus 5.69 g of monohydrate.
05
The evidence for a performance advantage over the monohydrate is not there. A randomised trial comparing creatine HCl with monohydrate alongside resistance training found gains in both supplemented groups; the case for the HCl form is formulation convenience and dose volume, not superiority. Do not let marketing copy outrun that.
06
Dicyandiamide and dihydrotriazine are the synthesis-related impurities EU buyers ask about on any creatine form. Have the limits ready before the question is asked.
05应用领域
应用领域
仅面向B2B生产用途——不作任何成品或功效宣称。
Low-volume-dose pre-workout and creatine capsules
Flavoured stick packs and ready-to-mix powders where dissolution is a selling point
Liquid and shot formats (with the caveat below)
Combination products with beta-alanine and citrulline
06各市场法规状态
各市场法规状态
以资料允许的最保守口径陈述原料的法规状态。这是供应链信息，不构成法规意见——成品与目的地市场的合规判断请咨询您自己的法规顾问。
| 市场 | 状态 | 依据 |
|---|---|---|
| United States | The FDA GRAS notice for creatine is specific to creatine MONOHYDRATE (GRN 931, notifier AlzChem Trostberg GmbH, closed with an 'FDA has no questions' letter in 2020). It does not extend to creatine hydrochloride. Creatine in any form is not listed in 21 CFR 172.320. US supplement marketing of creatine HCl rests on DSHEA. | FDA GRAS Notice Inventory GRN 931 (monohydrate only); 21 CFR 172.320 |
| European Union | Creatine monohydrate has an established position in EU food supplements; other creatine salts do not automatically share it and may need novel-food assessment. | Regulation (EU) 2015/2283 (novel foods); EU food supplement law |
| China | Status as a nutrient fortification substance / food additive under Chinese national standards to be confirmed. | GB 14880-2012 (nutrient fortification substances), GB 2760 (food additives), and NHC new-food-ingredient announcements |
| Japan | No JP XVIII Official Monograph for this substance was located. | JP XVIII |
07相关研究文献
相关研究文献
本化合物的同行评议文献，标识号均可点击直达原文——不必只听我们说。
以下文献仅用于提供科学背景。它们描述的是针对该化合物已发表的研究，既不是对本原料的宣称，也不是对任何成品的宣称。致诚生物不作任何医疗、健康或功效宣称。
- In a randomised trial, forty participants aged 18-25 undertook eight weeks of resistance training with creatine hydrochloride (0.03 g/kg/day), creatine monohydrate with or without a five-day loading phase, or placebo; strength, arm and thigh muscular cross-sectional area and skeletal muscle mass increased and body-fat percentage decreased significantly in the supplemented groups. Eghbali E, Arazi H, Suzuki K. Physiol Res. 2024;73(5):739-753. PMID 39545789DOI 10.33549/physiolres.935323原文
- In a randomised controlled trial in 36 perimenopausal and menopausal women, low- and medium-dose creatine hydrochloride (750 and 1,500 mg/day) alone or with creatine ethyl ester was evaluated over eight weeks for effects on cognitive function, clinical outcomes and brain creatine concentrations; the study was framed around low-dose creatine formulations with enhanced solubility. Korovljev D, Ostojic J, Panic J, et al. J Am Nutr Assoc. 2026;45(3):199-210. PMID 40854087DOI 10.1080/27697061.2025.2551184原文
- A multi-analytical study characterised creatine degradation under thermal stress (60-200 °C), UV exposure, pH variation (pH 3, 8 and 13) and common beverage matrices (coffee, orange juice and energy drink), using ATR-FTIR and high-resolution mass spectrometry to identify structural modifications relevant to storage, transport and preparation. Saiki PY, Sales GM, de Oliveira AN, Catharino RR. Food Res Int. 2025;221(Pt 3):117472. PMID 41214971DOI 10.1016/j.foodres.2025.117472原文
- A review reported that thermodynamic solubility of creatine monohydrate in water at 25 °C does not exceed 13 g/L, and surveyed micronisation and granulation approaches to improving dissolution rate and apparent solubility. Pharmaceuticals (Basel). 2026;19(1):128. PMID 41599726DOI 10.3390/ph19010128原文
08包装、储存与交期
包装、储存与交期
| 标准包装 | 25kg袋装、箱装或桶装 |
|---|---|
| 定制包装 | 长期客户可安排定制包装与标签 |
| 储存条件 | 阴凉干燥处，原包装密封保存 |
| 交期 | 按单备货——约1周到上海 |
| 运输 | 上海海运/空运拼货 · FOB/CIF/DDP按航线 |
09采购问答
采购问答
01Is creatine HCl better than monohydrate?
Better dissolving, not proven better performing — and we would rather say that than sell you a story. A randomised trial comparing the two alongside resistance training saw gains in both supplemented groups. Buy creatine HCl when you need dose volume or clear-liquid solubility. Buy monohydrate when you want the most creatine per dollar and the largest evidence base.
02How much creatine do I get per gram?
78.2% for the hydrochloride (131.13/167.59) against 87.9% for the monohydrate. A 5 g creatine dose needs 6.39 g of HCl salt versus 5.69 g of monohydrate. Tell us whether your target is creatine or salt weight on the RFQ.
03Which impurity limits should I insist on?
Creatinine first — it is the cyclisation degradation product and the industry's quality marker for every creatine form. Then dicyandiamide and dihydrotriazine, which are the synthesis-related impurities EU buyers ask about. A creatine COA without a creatinine limit is not a useful document.
04Can I put creatine HCl in a ready-to-drink beverage?
It will dissolve easily, which is the appeal — but understand the trade-off. Creatine converts to creatinine in solution and the reaction is acid-catalysed, so an acidic, freely soluble creatine salt mixes beautifully and can degrade faster on the shelf. Any liquid creatine programme needs real stability data at your pH and storage temperature, not an assumption.
05Does the FDA GRAS notice for creatine cover this?
No — and that distinction is worth getting right. GRN 931 is specific to creatine monohydrate. It does not extend to creatine hydrochloride. Take the compliance question for the HCl form to your own regulatory counsel.
06Creatine Hydrochloride 的起订量（MOQ）是多少？
MOQ按询盘灵活确定。在询盘中告知目标数量——核心现货SKU通常小试单与多吨位大单都可承接。
07下单前能否获取 Creatine Hydrochloride 样品？
可以——样品可按需提供，用于评估与实验室验证。在询盘中说明即可，我们逐单确认安排。
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